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Effects of Long-Term Temozolomide Treatment on Glioblastoma and Astrocytoma WHO Grade 4 Stem-like Cells

Glioblastoma leads to a fatal course within two years in more than two thirds of patients. An essential cornerstone of therapy is chemotherapy with temozolomide (TMZ). The effect of TMZ is counteracted by the cellular repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT). The MGMT promoter m...

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Detalles Bibliográficos
Autores principales:	Feldheim, Jonas, Kessler, Almuth F., Feldheim, Julia J., Schulz, Ellina, Wend, David, Lazaridis, Lazaros, Kleinschnitz, Christoph, Glas, Martin, Ernestus, Ralf-Ingo, Brandner, Sebastian, Monoranu, Camelia M., Löhr, Mario, Hagemann, Carsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100657/ https://www.ncbi.nlm.nih.gov/pubmed/35563629 http://dx.doi.org/10.3390/ijms23095238

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