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Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities
Six new diterpenoids, blusamiferoids A–F (1–6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera. Their structures were characterized by spectroscopic and comput...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100843/ https://www.ncbi.nlm.nih.gov/pubmed/35566241 http://dx.doi.org/10.3390/molecules27092890 |
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author | Huang, Xiao-Ling Wang, Dai-Wei Liu, Ying-Qian Cheng, Yong-Xian |
author_facet | Huang, Xiao-Ling Wang, Dai-Wei Liu, Ying-Qian Cheng, Yong-Xian |
author_sort | Huang, Xiao-Ling |
collection | PubMed |
description | Six new diterpenoids, blusamiferoids A–F (1–6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera. Their structures were characterized by spectroscopic and computational methods. In particular, the structures of 1 and 4 were confirmed by X-ray crystallography. Compounds 5 and 6 were found to dose-dependently inhibit the production of TNF-α, IL-6, and nitrite oxide, and compound 5 also downregulated NF-κB phosphorylation in lipopolysaccharide (LPS)-induced RAW 264.7 cells. |
format | Online Article Text |
id | pubmed-9100843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91008432022-05-14 Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities Huang, Xiao-Ling Wang, Dai-Wei Liu, Ying-Qian Cheng, Yong-Xian Molecules Article Six new diterpenoids, blusamiferoids A–F (1–6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera. Their structures were characterized by spectroscopic and computational methods. In particular, the structures of 1 and 4 were confirmed by X-ray crystallography. Compounds 5 and 6 were found to dose-dependently inhibit the production of TNF-α, IL-6, and nitrite oxide, and compound 5 also downregulated NF-κB phosphorylation in lipopolysaccharide (LPS)-induced RAW 264.7 cells. MDPI 2022-04-30 /pmc/articles/PMC9100843/ /pubmed/35566241 http://dx.doi.org/10.3390/molecules27092890 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Xiao-Ling Wang, Dai-Wei Liu, Ying-Qian Cheng, Yong-Xian Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities |
title | Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities |
title_full | Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities |
title_fullStr | Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities |
title_full_unstemmed | Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities |
title_short | Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities |
title_sort | diterpenoids from blumea balsamifera and their anti-inflammatory activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100843/ https://www.ncbi.nlm.nih.gov/pubmed/35566241 http://dx.doi.org/10.3390/molecules27092890 |
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