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Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities

Six new diterpenoids, blusamiferoids A–F (1–6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera. Their structures were characterized by spectroscopic and comput...

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Autores principales: Huang, Xiao-Ling, Wang, Dai-Wei, Liu, Ying-Qian, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100843/
https://www.ncbi.nlm.nih.gov/pubmed/35566241
http://dx.doi.org/10.3390/molecules27092890
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author Huang, Xiao-Ling
Wang, Dai-Wei
Liu, Ying-Qian
Cheng, Yong-Xian
author_facet Huang, Xiao-Ling
Wang, Dai-Wei
Liu, Ying-Qian
Cheng, Yong-Xian
author_sort Huang, Xiao-Ling
collection PubMed
description Six new diterpenoids, blusamiferoids A–F (1–6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera. Their structures were characterized by spectroscopic and computational methods. In particular, the structures of 1 and 4 were confirmed by X-ray crystallography. Compounds 5 and 6 were found to dose-dependently inhibit the production of TNF-α, IL-6, and nitrite oxide, and compound 5 also downregulated NF-κB phosphorylation in lipopolysaccharide (LPS)-induced RAW 264.7 cells.
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spelling pubmed-91008432022-05-14 Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities Huang, Xiao-Ling Wang, Dai-Wei Liu, Ying-Qian Cheng, Yong-Xian Molecules Article Six new diterpenoids, blusamiferoids A–F (1–6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera. Their structures were characterized by spectroscopic and computational methods. In particular, the structures of 1 and 4 were confirmed by X-ray crystallography. Compounds 5 and 6 were found to dose-dependently inhibit the production of TNF-α, IL-6, and nitrite oxide, and compound 5 also downregulated NF-κB phosphorylation in lipopolysaccharide (LPS)-induced RAW 264.7 cells. MDPI 2022-04-30 /pmc/articles/PMC9100843/ /pubmed/35566241 http://dx.doi.org/10.3390/molecules27092890 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Xiao-Ling
Wang, Dai-Wei
Liu, Ying-Qian
Cheng, Yong-Xian
Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities
title Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities
title_full Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities
title_fullStr Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities
title_full_unstemmed Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities
title_short Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities
title_sort diterpenoids from blumea balsamifera and their anti-inflammatory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100843/
https://www.ncbi.nlm.nih.gov/pubmed/35566241
http://dx.doi.org/10.3390/molecules27092890
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