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Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes

A novel biologically active thiosemicarbazide derivative ligand L (N-[(phenylcarbamothioyl)amino]pyridine-3-carboxamide) and a series of its five metal(II) complexes, namely: [Co(L)Cl(2)], [Ni(L)Cl(2)(H(2)O)], [Cu(L)Cl(2)(H(2)O)], [Zn(L)Cl(2)] and [Cd(L)Cl(2)(H(2)O)] have been synthesized and thorou...

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Detalles Bibliográficos
Autores principales: Rogalewicz, Bartłomiej, Climova, Alina, Pivovarova, Ekaterina, Sukiennik, Jarosław, Czarnecka, Kamila, Szymański, Paweł, Szczesio, Małgorzata, Gas, Katarzyna, Sawicki, Maciej, Pitucha, Monika, Czylkowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100868/
https://www.ncbi.nlm.nih.gov/pubmed/35566053
http://dx.doi.org/10.3390/molecules27092703
Descripción
Sumario:A novel biologically active thiosemicarbazide derivative ligand L (N-[(phenylcarbamothioyl)amino]pyridine-3-carboxamide) and a series of its five metal(II) complexes, namely: [Co(L)Cl(2)], [Ni(L)Cl(2)(H(2)O)], [Cu(L)Cl(2)(H(2)O)], [Zn(L)Cl(2)] and [Cd(L)Cl(2)(H(2)O)] have been synthesized and thoroughly investigated. The physicochemical characterization of the newly obtained compounds has been performed using appropriate analytical techniques, such as (1)H and (l3)C nuclear magnetic resonance (NMR), inductively coupled plasma (ICP), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR) and magnetic measurements. In order to study the pharmacokinetic profile of the compounds, ADMET analysis was performed. The in vitro studies revealed that the synthesized compounds exhibit potent biological activity against A549 human cancer cell line.