Semi-Synthesis of N-Aryl Amide Analogs of Piperine from Piper nigrum and Evaluation of Their Antitrypanosomal, Antimalarial, and Anti-SARS-CoV-2 Main Protease Activities

Piper nigrum, or black pepper, produces piperine, an alkaloid that has diverse pharmacological activities. In this study, N-aryl amide piperine analogs were prepared by semi-synthesis involving the saponification of piperine (1) to yield piperic acid (2) followed by esterification to obtain compound...

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Detalles Bibliográficos
Autores principales: Wansri, Rattanaporn, Lin, Aye Chan Khine, Pengon, Jutharat, Kamchonwongpaisan, Sumalee, Srimongkolpithak, Nitipol, Rattanajak, Roonglawan, Wilasluck, Patcharin, Deetanya, Peerapon, Wangkanont, Kittikhun, Hengphasatporn, Kowit, Shigeta, Yasuteru, Liangsakul, Jatupol, Suroengrit, Aphinya, Boonyasuppayakorn, Siwaporn, Chuanasa, Taksina, De-eknamkul, Wanchai, Hannongbua, Supot, Rungrotmongkol, Thanyada, Chamni, Supakarn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100884/
https://www.ncbi.nlm.nih.gov/pubmed/35566194
http://dx.doi.org/10.3390/molecules27092841

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