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Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction

Background: Elevated levels of C-reactive protein (CRP) are associated with both an increased risk of cardiovascular disease (CVD) and depression. We aimed to test the hypothesis that a self-report history of depression is associated with a smaller decrease in CRP levels from hospital admission to 3...

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Autores principales: Bielas, Hannes, Meister-Langraf, Rebecca E., Schmid, Jean-Paul, Barth, Jürgen, Znoj, Hansjörg, Schnyder, Ulrich, Princip, Mary, von Känel, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100988/
https://www.ncbi.nlm.nih.gov/pubmed/35566447
http://dx.doi.org/10.3390/jcm11092322
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author Bielas, Hannes
Meister-Langraf, Rebecca E.
Schmid, Jean-Paul
Barth, Jürgen
Znoj, Hansjörg
Schnyder, Ulrich
Princip, Mary
von Känel, Roland
author_facet Bielas, Hannes
Meister-Langraf, Rebecca E.
Schmid, Jean-Paul
Barth, Jürgen
Znoj, Hansjörg
Schnyder, Ulrich
Princip, Mary
von Känel, Roland
author_sort Bielas, Hannes
collection PubMed
description Background: Elevated levels of C-reactive protein (CRP) are associated with both an increased risk of cardiovascular disease (CVD) and depression. We aimed to test the hypothesis that a self-report history of depression is associated with a smaller decrease in CRP levels from hospital admission to 3-month follow-up in patients with acute myocardial infarction (MI). Methods: We assessed 183 patients (median age 59 years; 84% men) with verified MI for a self-report history of lifetime depression and plasma CRP levels within 48 h of an acute coronary intervention and again for CRP levels at three months. CRP values were categorized according to their potential to predict CVD risk at hospital admission (acute inflammatory response: 0 to <5 mg/L, 5 to <10 mg/L, 10 to <20 mg/L, and ≥20 mg/L) and at 3 months (low-grade inflammation: 0 to <1 mg/L, 1 to <3 mg/L, and ≥3 mg/L). Additionally, in a subsample of 84 patients showing admission CRP levels below 20 mg/L, changes in continuous CRP values over time were also analyzed. Results: After adjustment for a range of potentially important covariates, depression history showed a significant association with a smaller decrease in both CRP risk categories (r = 0.261, p < 0.001) and log CRP levels (r = 0.340, p = 0.005) over time. Conclusions: Self-reported history of depression may be associated with persistently elevated systemic inflammation three months after MI. This finding warrants studies to test whether lowering of inflammation in patients with an acute MI and a history of depression may improve prognosis.
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spelling pubmed-91009882022-05-14 Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction Bielas, Hannes Meister-Langraf, Rebecca E. Schmid, Jean-Paul Barth, Jürgen Znoj, Hansjörg Schnyder, Ulrich Princip, Mary von Känel, Roland J Clin Med Article Background: Elevated levels of C-reactive protein (CRP) are associated with both an increased risk of cardiovascular disease (CVD) and depression. We aimed to test the hypothesis that a self-report history of depression is associated with a smaller decrease in CRP levels from hospital admission to 3-month follow-up in patients with acute myocardial infarction (MI). Methods: We assessed 183 patients (median age 59 years; 84% men) with verified MI for a self-report history of lifetime depression and plasma CRP levels within 48 h of an acute coronary intervention and again for CRP levels at three months. CRP values were categorized according to their potential to predict CVD risk at hospital admission (acute inflammatory response: 0 to <5 mg/L, 5 to <10 mg/L, 10 to <20 mg/L, and ≥20 mg/L) and at 3 months (low-grade inflammation: 0 to <1 mg/L, 1 to <3 mg/L, and ≥3 mg/L). Additionally, in a subsample of 84 patients showing admission CRP levels below 20 mg/L, changes in continuous CRP values over time were also analyzed. Results: After adjustment for a range of potentially important covariates, depression history showed a significant association with a smaller decrease in both CRP risk categories (r = 0.261, p < 0.001) and log CRP levels (r = 0.340, p = 0.005) over time. Conclusions: Self-reported history of depression may be associated with persistently elevated systemic inflammation three months after MI. This finding warrants studies to test whether lowering of inflammation in patients with an acute MI and a history of depression may improve prognosis. MDPI 2022-04-21 /pmc/articles/PMC9100988/ /pubmed/35566447 http://dx.doi.org/10.3390/jcm11092322 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bielas, Hannes
Meister-Langraf, Rebecca E.
Schmid, Jean-Paul
Barth, Jürgen
Znoj, Hansjörg
Schnyder, Ulrich
Princip, Mary
von Känel, Roland
Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction
title Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction
title_full Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction
title_fullStr Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction
title_full_unstemmed Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction
title_short Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction
title_sort relationship between a self-reported history of depression and persistent elevation in c-reactive protein after myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100988/
https://www.ncbi.nlm.nih.gov/pubmed/35566447
http://dx.doi.org/10.3390/jcm11092322
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