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Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food

Various gluten-related diseases (celiac disease, wheat allergy, gluten sensitivity) are known and their incidence is growing. Gluten is a specific type of plant storage protein that can impair the health of gluten-prone persons following consumption, depending on the origin. The most severe effects...

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Autores principales: Ranftler, Carmen, Röhrich, Andreas, Sparer, Andreas, Tschegg, Cornelius, Nagl, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101028/
https://www.ncbi.nlm.nih.gov/pubmed/35563533
http://dx.doi.org/10.3390/ijms23095143
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author Ranftler, Carmen
Röhrich, Andreas
Sparer, Andreas
Tschegg, Cornelius
Nagl, Dietmar
author_facet Ranftler, Carmen
Röhrich, Andreas
Sparer, Andreas
Tschegg, Cornelius
Nagl, Dietmar
author_sort Ranftler, Carmen
collection PubMed
description Various gluten-related diseases (celiac disease, wheat allergy, gluten sensitivity) are known and their incidence is growing. Gluten is a specific type of plant storage protein that can impair the health of gluten-prone persons following consumption, depending on the origin. The most severe effects are induced by wheat, barley, and rye. The only treatment is based on the absolute avoidance of those foods, as even traces might have severe effects on human well-being. With the goal of binding gluten impurities after ingestion, an in vitro setting was created. A special processed kind of zeolite, purified clinoptilolite-tuff (PCT), was implemented as an adsorber of gluten derived from different origins. Zeolites are known for their excellent sorption capacities and their applications in humans and animals have been studied for a long time. Tests were also performed in artificial gastric and intestinal fluids, and the adsorption capacity was determined via a certified validated method (ELISA). Depending on the kind of gluten source, 80–130 µg/mg of gluten were bound onto PCT. Hence, purified clinoptilolite-tuff, which was successfully tested for wheat, barley, and rye, proved to be suitable for the adsorption of gluten originating from different kinds of crops. This result might form the basis for an expedient human study in the future.
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spelling pubmed-91010282022-05-14 Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food Ranftler, Carmen Röhrich, Andreas Sparer, Andreas Tschegg, Cornelius Nagl, Dietmar Int J Mol Sci Article Various gluten-related diseases (celiac disease, wheat allergy, gluten sensitivity) are known and their incidence is growing. Gluten is a specific type of plant storage protein that can impair the health of gluten-prone persons following consumption, depending on the origin. The most severe effects are induced by wheat, barley, and rye. The only treatment is based on the absolute avoidance of those foods, as even traces might have severe effects on human well-being. With the goal of binding gluten impurities after ingestion, an in vitro setting was created. A special processed kind of zeolite, purified clinoptilolite-tuff (PCT), was implemented as an adsorber of gluten derived from different origins. Zeolites are known for their excellent sorption capacities and their applications in humans and animals have been studied for a long time. Tests were also performed in artificial gastric and intestinal fluids, and the adsorption capacity was determined via a certified validated method (ELISA). Depending on the kind of gluten source, 80–130 µg/mg of gluten were bound onto PCT. Hence, purified clinoptilolite-tuff, which was successfully tested for wheat, barley, and rye, proved to be suitable for the adsorption of gluten originating from different kinds of crops. This result might form the basis for an expedient human study in the future. MDPI 2022-05-05 /pmc/articles/PMC9101028/ /pubmed/35563533 http://dx.doi.org/10.3390/ijms23095143 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ranftler, Carmen
Röhrich, Andreas
Sparer, Andreas
Tschegg, Cornelius
Nagl, Dietmar
Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food
title Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food
title_full Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food
title_fullStr Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food
title_full_unstemmed Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food
title_short Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food
title_sort purified clinoptilolite-tuff as an efficient sorbent for gluten derived from food
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101028/
https://www.ncbi.nlm.nih.gov/pubmed/35563533
http://dx.doi.org/10.3390/ijms23095143
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