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Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids

The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted using chloroform or dichloromethane. This procedu...

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Autores principales: Strzemski, Maciej, Dresler, Sławomir, Podkościelna, Beata, Skic, Kamil, Sowa, Ireneusz, Załuski, Daniel, Verpoorte, Rob, Zielińska, Sylwia, Krawczyk, Paweł, Wójciak, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101032/
https://www.ncbi.nlm.nih.gov/pubmed/35566166
http://dx.doi.org/10.3390/molecules27092815
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author Strzemski, Maciej
Dresler, Sławomir
Podkościelna, Beata
Skic, Kamil
Sowa, Ireneusz
Załuski, Daniel
Verpoorte, Rob
Zielińska, Sylwia
Krawczyk, Paweł
Wójciak, Magdalena
author_facet Strzemski, Maciej
Dresler, Sławomir
Podkościelna, Beata
Skic, Kamil
Sowa, Ireneusz
Załuski, Daniel
Verpoorte, Rob
Zielińska, Sylwia
Krawczyk, Paweł
Wójciak, Magdalena
author_sort Strzemski, Maciej
collection PubMed
description The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted using chloroform or dichloromethane. This procedure requires the use of toxic solvents. The present study assessed the possibility of using volatile natural deep eutectic solvents (VNADESs) for the efficient and environmentally friendly extraction of Chelidonium alkaloids. The roots and herb of the plant were subjected three times to extraction with various menthol, thymol, and camphor mixtures and with water and methanol (acidified and nonacidified). It has been shown that alkaloids can be efficiently isolated using menthol–camphor and menthol–thymol mixtures. In comparison with the extraction with acidified methanol, the use of appropriate VNADESs formulations yielded higher amounts of protopine (by 16%), chelidonine (35%), berberine (76%), chelerythrine (12%), and coptisine (180%). Sanguinarine extraction efficiency was at the same level. Additionally, the values of the contact angles of the raw materials treated with the tested solvents were assessed, and higher wetting dynamics were observed in the case of VNADESs when compared with water. These results suggest that VNADESs can be used for the efficient and environmentally friendly extraction of Chelidonium alkaloids.
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spelling pubmed-91010322022-05-14 Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids Strzemski, Maciej Dresler, Sławomir Podkościelna, Beata Skic, Kamil Sowa, Ireneusz Załuski, Daniel Verpoorte, Rob Zielińska, Sylwia Krawczyk, Paweł Wójciak, Magdalena Molecules Communication The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted using chloroform or dichloromethane. This procedure requires the use of toxic solvents. The present study assessed the possibility of using volatile natural deep eutectic solvents (VNADESs) for the efficient and environmentally friendly extraction of Chelidonium alkaloids. The roots and herb of the plant were subjected three times to extraction with various menthol, thymol, and camphor mixtures and with water and methanol (acidified and nonacidified). It has been shown that alkaloids can be efficiently isolated using menthol–camphor and menthol–thymol mixtures. In comparison with the extraction with acidified methanol, the use of appropriate VNADESs formulations yielded higher amounts of protopine (by 16%), chelidonine (35%), berberine (76%), chelerythrine (12%), and coptisine (180%). Sanguinarine extraction efficiency was at the same level. Additionally, the values of the contact angles of the raw materials treated with the tested solvents were assessed, and higher wetting dynamics were observed in the case of VNADESs when compared with water. These results suggest that VNADESs can be used for the efficient and environmentally friendly extraction of Chelidonium alkaloids. MDPI 2022-04-28 /pmc/articles/PMC9101032/ /pubmed/35566166 http://dx.doi.org/10.3390/molecules27092815 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Strzemski, Maciej
Dresler, Sławomir
Podkościelna, Beata
Skic, Kamil
Sowa, Ireneusz
Załuski, Daniel
Verpoorte, Rob
Zielińska, Sylwia
Krawczyk, Paweł
Wójciak, Magdalena
Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids
title Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids
title_full Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids
title_fullStr Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids
title_full_unstemmed Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids
title_short Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids
title_sort effectiveness of volatile natural deep eutectic solvents (vnadess) for the green extraction of chelidonium majus isoquinoline alkaloids
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101032/
https://www.ncbi.nlm.nih.gov/pubmed/35566166
http://dx.doi.org/10.3390/molecules27092815
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