Cargando…
Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids
The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted using chloroform or dichloromethane. This procedu...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101032/ https://www.ncbi.nlm.nih.gov/pubmed/35566166 http://dx.doi.org/10.3390/molecules27092815 |
_version_ | 1784706985850044416 |
---|---|
author | Strzemski, Maciej Dresler, Sławomir Podkościelna, Beata Skic, Kamil Sowa, Ireneusz Załuski, Daniel Verpoorte, Rob Zielińska, Sylwia Krawczyk, Paweł Wójciak, Magdalena |
author_facet | Strzemski, Maciej Dresler, Sławomir Podkościelna, Beata Skic, Kamil Sowa, Ireneusz Załuski, Daniel Verpoorte, Rob Zielińska, Sylwia Krawczyk, Paweł Wójciak, Magdalena |
author_sort | Strzemski, Maciej |
collection | PubMed |
description | The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted using chloroform or dichloromethane. This procedure requires the use of toxic solvents. The present study assessed the possibility of using volatile natural deep eutectic solvents (VNADESs) for the efficient and environmentally friendly extraction of Chelidonium alkaloids. The roots and herb of the plant were subjected three times to extraction with various menthol, thymol, and camphor mixtures and with water and methanol (acidified and nonacidified). It has been shown that alkaloids can be efficiently isolated using menthol–camphor and menthol–thymol mixtures. In comparison with the extraction with acidified methanol, the use of appropriate VNADESs formulations yielded higher amounts of protopine (by 16%), chelidonine (35%), berberine (76%), chelerythrine (12%), and coptisine (180%). Sanguinarine extraction efficiency was at the same level. Additionally, the values of the contact angles of the raw materials treated with the tested solvents were assessed, and higher wetting dynamics were observed in the case of VNADESs when compared with water. These results suggest that VNADESs can be used for the efficient and environmentally friendly extraction of Chelidonium alkaloids. |
format | Online Article Text |
id | pubmed-9101032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91010322022-05-14 Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids Strzemski, Maciej Dresler, Sławomir Podkościelna, Beata Skic, Kamil Sowa, Ireneusz Załuski, Daniel Verpoorte, Rob Zielińska, Sylwia Krawczyk, Paweł Wójciak, Magdalena Molecules Communication The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted using chloroform or dichloromethane. This procedure requires the use of toxic solvents. The present study assessed the possibility of using volatile natural deep eutectic solvents (VNADESs) for the efficient and environmentally friendly extraction of Chelidonium alkaloids. The roots and herb of the plant were subjected three times to extraction with various menthol, thymol, and camphor mixtures and with water and methanol (acidified and nonacidified). It has been shown that alkaloids can be efficiently isolated using menthol–camphor and menthol–thymol mixtures. In comparison with the extraction with acidified methanol, the use of appropriate VNADESs formulations yielded higher amounts of protopine (by 16%), chelidonine (35%), berberine (76%), chelerythrine (12%), and coptisine (180%). Sanguinarine extraction efficiency was at the same level. Additionally, the values of the contact angles of the raw materials treated with the tested solvents were assessed, and higher wetting dynamics were observed in the case of VNADESs when compared with water. These results suggest that VNADESs can be used for the efficient and environmentally friendly extraction of Chelidonium alkaloids. MDPI 2022-04-28 /pmc/articles/PMC9101032/ /pubmed/35566166 http://dx.doi.org/10.3390/molecules27092815 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Strzemski, Maciej Dresler, Sławomir Podkościelna, Beata Skic, Kamil Sowa, Ireneusz Załuski, Daniel Verpoorte, Rob Zielińska, Sylwia Krawczyk, Paweł Wójciak, Magdalena Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids |
title | Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids |
title_full | Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids |
title_fullStr | Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids |
title_full_unstemmed | Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids |
title_short | Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids |
title_sort | effectiveness of volatile natural deep eutectic solvents (vnadess) for the green extraction of chelidonium majus isoquinoline alkaloids |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101032/ https://www.ncbi.nlm.nih.gov/pubmed/35566166 http://dx.doi.org/10.3390/molecules27092815 |
work_keys_str_mv | AT strzemskimaciej effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT dreslersławomir effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT podkoscielnabeata effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT skickamil effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT sowaireneusz effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT załuskidaniel effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT verpoorterob effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT zielinskasylwia effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT krawczykpaweł effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids AT wojciakmagdalena effectivenessofvolatilenaturaldeepeutecticsolventsvnadessforthegreenextractionofchelidoniummajusisoquinolinealkaloids |