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Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function

Epinephrine is the most abundant catecholamine hormone, produced by the nervous system and adrenal glands. Endocrine disruption of epinephrine synthesis, secretion and signaling is less studied than steroid and thyroid hormones. Dichlorodiphenyltrichloroethane (DDT) is recognized as one of the most...

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Autores principales: Yaglova, Nataliya V., Obernikhin, Sergey S., Tsomartova, Dibakhan A., Yaglov, Valentin V., Nazimova, Svetlana V., Tsomartova, Elina S., Timokhina, Ekaterina P., Chereshneva, Elizaveta V., Ivanova, Marina Y., Lomanovskaya, Tatiana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101091/
https://www.ncbi.nlm.nih.gov/pubmed/35563302
http://dx.doi.org/10.3390/ijms23094912
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author Yaglova, Nataliya V.
Obernikhin, Sergey S.
Tsomartova, Dibakhan A.
Yaglov, Valentin V.
Nazimova, Svetlana V.
Tsomartova, Elina S.
Timokhina, Ekaterina P.
Chereshneva, Elizaveta V.
Ivanova, Marina Y.
Lomanovskaya, Tatiana A.
author_facet Yaglova, Nataliya V.
Obernikhin, Sergey S.
Tsomartova, Dibakhan A.
Yaglov, Valentin V.
Nazimova, Svetlana V.
Tsomartova, Elina S.
Timokhina, Ekaterina P.
Chereshneva, Elizaveta V.
Ivanova, Marina Y.
Lomanovskaya, Tatiana A.
author_sort Yaglova, Nataliya V.
collection PubMed
description Epinephrine is the most abundant catecholamine hormone, produced by the nervous system and adrenal glands. Endocrine disruption of epinephrine synthesis, secretion and signaling is less studied than steroid and thyroid hormones. Dichlorodiphenyltrichloroethane (DDT) is recognized as one of the most prominent environmental contaminants with a long half-life. It is a potent endocrine disrupter affecting sex steroid, mineralocorticoid, glucocorticoid and thyroid hormone production. Exposure to low doses of DDT is universal and begins in utero. Therefore, we studied adrenal medulla growth and function in male Wistar rats exposed to low doses of DDT during prenatal and postnatal development until puberty and adulthood, as well as rats exposed to DDT since the first day of postnatal development. All the exposed rats demonstrated lowered epinephrine blood levels, gradually reducing with age. DDT was found to inhibit the synthesis of tyrosine hydroxylase and affect the mitochondrial apparatus of epinephrine-producing cells during puberty and even after maturation. Low-dose exposure to DDT from birth resulted in more pronounced changes in adrenomedullary cells and a more profound decrease (up to 50%) in epinephrine secretion in adult rats. Prenatal onset of exposure demonstrated a mild effect on epinephrine-producing function (30% reduction), but was associated with lower rate of adrenal medulla growth during maturation and 25% smaller adrenal medullar size in adult rats. All subjects exposed to low doses of DDT failed to develop adaptive changes and restore proper epinephrine production. These results indicate a dysmorphogenetic effect of prenatal exposure and disruption of secretory function of adrenal chromaffin cells by postnatal exposure to DDT.
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spelling pubmed-91010912022-05-14 Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function Yaglova, Nataliya V. Obernikhin, Sergey S. Tsomartova, Dibakhan A. Yaglov, Valentin V. Nazimova, Svetlana V. Tsomartova, Elina S. Timokhina, Ekaterina P. Chereshneva, Elizaveta V. Ivanova, Marina Y. Lomanovskaya, Tatiana A. Int J Mol Sci Article Epinephrine is the most abundant catecholamine hormone, produced by the nervous system and adrenal glands. Endocrine disruption of epinephrine synthesis, secretion and signaling is less studied than steroid and thyroid hormones. Dichlorodiphenyltrichloroethane (DDT) is recognized as one of the most prominent environmental contaminants with a long half-life. It is a potent endocrine disrupter affecting sex steroid, mineralocorticoid, glucocorticoid and thyroid hormone production. Exposure to low doses of DDT is universal and begins in utero. Therefore, we studied adrenal medulla growth and function in male Wistar rats exposed to low doses of DDT during prenatal and postnatal development until puberty and adulthood, as well as rats exposed to DDT since the first day of postnatal development. All the exposed rats demonstrated lowered epinephrine blood levels, gradually reducing with age. DDT was found to inhibit the synthesis of tyrosine hydroxylase and affect the mitochondrial apparatus of epinephrine-producing cells during puberty and even after maturation. Low-dose exposure to DDT from birth resulted in more pronounced changes in adrenomedullary cells and a more profound decrease (up to 50%) in epinephrine secretion in adult rats. Prenatal onset of exposure demonstrated a mild effect on epinephrine-producing function (30% reduction), but was associated with lower rate of adrenal medulla growth during maturation and 25% smaller adrenal medullar size in adult rats. All subjects exposed to low doses of DDT failed to develop adaptive changes and restore proper epinephrine production. These results indicate a dysmorphogenetic effect of prenatal exposure and disruption of secretory function of adrenal chromaffin cells by postnatal exposure to DDT. MDPI 2022-04-28 /pmc/articles/PMC9101091/ /pubmed/35563302 http://dx.doi.org/10.3390/ijms23094912 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yaglova, Nataliya V.
Obernikhin, Sergey S.
Tsomartova, Dibakhan A.
Yaglov, Valentin V.
Nazimova, Svetlana V.
Tsomartova, Elina S.
Timokhina, Ekaterina P.
Chereshneva, Elizaveta V.
Ivanova, Marina Y.
Lomanovskaya, Tatiana A.
Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function
title Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function
title_full Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function
title_fullStr Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function
title_full_unstemmed Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function
title_short Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function
title_sort impact of prenatal and postnatal exposure to endocrine disrupter ddt on adrenal medulla function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101091/
https://www.ncbi.nlm.nih.gov/pubmed/35563302
http://dx.doi.org/10.3390/ijms23094912
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