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Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil

New variants of SARS-CoV-2 are a major source of concern, especially for pregnant women and in the perinatal context. The primary aim of this study was to compare the severity of COVID-19 infection in pregnant women depending on strain predominance between wild-type Alpha and Gamma variants. The sec...

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Autores principales: Mosnino, Elie, Bernardes, Lisandra S., Mattern, Jeremie, Hipólito Micheletti, Bruna, Aparecida de Castro Maldonado, Amarilis, Vauloup-Fellous, Christelle, Doucet-Populaire, Florence, De Luca, Daniele, Benachi, Alexandra, Vivanti, Alexandre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101133/
https://www.ncbi.nlm.nih.gov/pubmed/35566787
http://dx.doi.org/10.3390/jcm11092663
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author Mosnino, Elie
Bernardes, Lisandra S.
Mattern, Jeremie
Hipólito Micheletti, Bruna
Aparecida de Castro Maldonado, Amarilis
Vauloup-Fellous, Christelle
Doucet-Populaire, Florence
De Luca, Daniele
Benachi, Alexandra
Vivanti, Alexandre J.
author_facet Mosnino, Elie
Bernardes, Lisandra S.
Mattern, Jeremie
Hipólito Micheletti, Bruna
Aparecida de Castro Maldonado, Amarilis
Vauloup-Fellous, Christelle
Doucet-Populaire, Florence
De Luca, Daniele
Benachi, Alexandra
Vivanti, Alexandre J.
author_sort Mosnino, Elie
collection PubMed
description New variants of SARS-CoV-2 are a major source of concern, especially for pregnant women and in the perinatal context. The primary aim of this study was to compare the severity of COVID-19 infection in pregnant women depending on strain predominance between wild-type Alpha and Gamma variants. The secondary aim was to study the impact of these strains on obstetrical and neonatal outcomes. We conducted a two-center international retrospective cohort study, which included two type III maternity hospitals, one in France and one in Brazil, comparing the first period corresponding to the wild-type strain and the second period corresponding to the predominance of the Alpha variant in France and the Gamma variant in Brazil. We included 151 pregnant women with symptomatic SARS-CoV-2 infection confirmed by RT-PCR. The rate of severe-to-critical infection, according to the WHO definition, was seven-fold higher in patients infected during the “variant period” than in patients infected during the “wild-type period” (aOR = 7.07, 95CI [2.50–21.6], p < 0.001). There were no statistical differences concerning composite obstetrical and neonatal outcomes between the different periods. While analyzing each variant separately, it was found that, in France, the risk of developing a severe-to-critical infection was three times greater during the Alpha period than during the wild-type period (OR = 3.25, 95CI [0.70–15.6], p = 0.13) and, in Brazil, the risk was twelve times greater during the Gamma period than during the wild-type period (OR = 11.8, 95CI [2.46–72.3], p = 0.003). The Alpha and Gamma variants of SARS-CoV-2 seem to be more dangerous in the obstetrical context. With the rapid emergence of new variants, it is necessary to accelerate vaccination to protect women and newborn children.
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spelling pubmed-91011332022-05-14 Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil Mosnino, Elie Bernardes, Lisandra S. Mattern, Jeremie Hipólito Micheletti, Bruna Aparecida de Castro Maldonado, Amarilis Vauloup-Fellous, Christelle Doucet-Populaire, Florence De Luca, Daniele Benachi, Alexandra Vivanti, Alexandre J. J Clin Med Article New variants of SARS-CoV-2 are a major source of concern, especially for pregnant women and in the perinatal context. The primary aim of this study was to compare the severity of COVID-19 infection in pregnant women depending on strain predominance between wild-type Alpha and Gamma variants. The secondary aim was to study the impact of these strains on obstetrical and neonatal outcomes. We conducted a two-center international retrospective cohort study, which included two type III maternity hospitals, one in France and one in Brazil, comparing the first period corresponding to the wild-type strain and the second period corresponding to the predominance of the Alpha variant in France and the Gamma variant in Brazil. We included 151 pregnant women with symptomatic SARS-CoV-2 infection confirmed by RT-PCR. The rate of severe-to-critical infection, according to the WHO definition, was seven-fold higher in patients infected during the “variant period” than in patients infected during the “wild-type period” (aOR = 7.07, 95CI [2.50–21.6], p < 0.001). There were no statistical differences concerning composite obstetrical and neonatal outcomes between the different periods. While analyzing each variant separately, it was found that, in France, the risk of developing a severe-to-critical infection was three times greater during the Alpha period than during the wild-type period (OR = 3.25, 95CI [0.70–15.6], p = 0.13) and, in Brazil, the risk was twelve times greater during the Gamma period than during the wild-type period (OR = 11.8, 95CI [2.46–72.3], p = 0.003). The Alpha and Gamma variants of SARS-CoV-2 seem to be more dangerous in the obstetrical context. With the rapid emergence of new variants, it is necessary to accelerate vaccination to protect women and newborn children. MDPI 2022-05-09 /pmc/articles/PMC9101133/ /pubmed/35566787 http://dx.doi.org/10.3390/jcm11092663 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mosnino, Elie
Bernardes, Lisandra S.
Mattern, Jeremie
Hipólito Micheletti, Bruna
Aparecida de Castro Maldonado, Amarilis
Vauloup-Fellous, Christelle
Doucet-Populaire, Florence
De Luca, Daniele
Benachi, Alexandra
Vivanti, Alexandre J.
Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil
title Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil
title_full Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil
title_fullStr Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil
title_full_unstemmed Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil
title_short Impact of SARS-CoV-2 Alpha and Gamma Variants among Symptomatic Pregnant Women: A Two-Center Retrospective Cohort Study between France and Brazil
title_sort impact of sars-cov-2 alpha and gamma variants among symptomatic pregnant women: a two-center retrospective cohort study between france and brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101133/
https://www.ncbi.nlm.nih.gov/pubmed/35566787
http://dx.doi.org/10.3390/jcm11092663
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