Clinical Evaluation of Nuclear Imaging Agents in Breast Cancer

SIMPLE SUMMARY: Breast cancer is currently the most common type of diagnosed cancer worldwide. Noninvasive imaging of therapeutic targets or biomarkers for breast cancer has the potential to contribute to precision medicine, where targeted therapy is needed. Positron emission tomography (PET) or single-photon emission tomography (SPECT) imaging with radiolabeled probes has the potential to play an important role in the molecular profiling of therapeutic targets in vivo for the selection of patients who are likely to respond to corresponding targeted therapy. This review covers recent clinical investigations with noninvasive imaging agents in breast cancer. We reviewed 17 clinical studies on PET or SPECT agents that target 10 receptors in breast cancer. ABSTRACT: Precision medicine is the customization of therapy for specific groups of patients using genetic or molecular profiling. Noninvasive imaging is one strategy for molecular profiling and is the focus of this review. The combination of imaging and therapy for precision medicine gave rise to the field of theranostics. In breast cancer, the detection and quantification of therapeutic targets can help assess their heterogeneity, especially in metastatic disease, and may help guide clinical decisions for targeted treatments. Positron emission tomography (PET) or single-photon emission tomography (SPECT) imaging has the potential to play an important role in the molecular profiling of therapeutic targets in vivo for the selection of patients who are likely to respond to corresponding targeted therapy. In this review, we discuss the state-of-the-art nuclear imaging agents in clinical research for breast cancer. We reviewed 17 clinical studies on PET or SPECT agents that target 10 different receptors in breast cancer. We also discuss the limitations of the study designs and of the imaging agents in these studies. Finally, we offer our perspective on which imaging agents have the highest potential to be used in clinical practice in the future.