Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding

Rising incidences and mortalities have drawn attention to Clostridioides difficile infections (CDIs) in recent years. The main virulence factors of this bacterium are the exotoxins TcdA and TcdB, which glucosylate Rho-GTPases and thereby inhibit Rho/actin-mediated processes in cells. This results in...

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Detalles Bibliográficos
Autores principales: Barthold, Lara, Heber, Sebastian, Schmidt, Christoph Q., Gradl, Marion, Weidinger, Gilbert, Barth, Holger, Fischer, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101188/
https://www.ncbi.nlm.nih.gov/pubmed/35562899
http://dx.doi.org/10.3390/ijms23094509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101188/
https://www.ncbi.nlm.nih.gov/pubmed/35562899
http://dx.doi.org/10.3390/ijms23094509

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