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Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program

Dopamine receptor D2 gene (DRD2) polymorphisms have been associated with cognitive abilities, obesity, addictions, and physical-activity-related behaviors, which may underlie differences in the effectiveness of training programs. What is not yet clear is the impact of DRD2 polymorphisms on the effec...

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Autores principales: Świtała, Katarzyna, Bojarczuk, Aleksandra, Hajto, Jacek, Piechota, Marcin, Buryta, Maciej, Leońska-Duniec, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101192/
https://www.ncbi.nlm.nih.gov/pubmed/35564336
http://dx.doi.org/10.3390/ijerph19094942
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author Świtała, Katarzyna
Bojarczuk, Aleksandra
Hajto, Jacek
Piechota, Marcin
Buryta, Maciej
Leońska-Duniec, Agata
author_facet Świtała, Katarzyna
Bojarczuk, Aleksandra
Hajto, Jacek
Piechota, Marcin
Buryta, Maciej
Leońska-Duniec, Agata
author_sort Świtała, Katarzyna
collection PubMed
description Dopamine receptor D2 gene (DRD2) polymorphisms have been associated with cognitive abilities, obesity, addictions, and physical-activity-related behaviors, which may underlie differences in the effectiveness of training programs. What is not yet clear is the impact of DRD2 polymorphisms on the effectiveness of exercise programs. Thus, the aim of this study was to investigate the association between the DRD2 polymorphic sites (rs1076560, rs12364283, rs1799732, rs1800497, and rs1800498) and the body’s response to regular physical activity. We studied genotypes and haplotypes distribution in a group of 165 females measured for body mass and body composition measurements, lipid profile, and glucose levels before and after realization of a 12-week training program. When tested individually, statistical analyses revealed one significant genotype by training interaction under the general model (for the basal metabolic rate, BMR, p = 0.033). Carriers of the rs1076560 CC genotype exhibited a decrease in BMR in response to training (p = 0.006). Haplotype analyses also showed that (i) the CACCC and CACTT haplotypes were associated with a post-training decrease in glucose level (β = −4.11, p = 0.032; β = −6.86, p = 0.020, respectively); (ii) the CGCCT with an increase in BMR (β = 0.65, p = 0.003) and fat free mass (FFM, β = 1.20, p = 0.009); (iii) the CA-CT with a decrease in low-density lipoprotein cholesterol (LDL, β = −17.26, p = 0.046). These results provide some evidence that the DRD2 polymorphisms may play a role in post-training changes in lipid and carbohydrate metabolism, and, as a consequence, in the effectiveness of training programs.
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spelling pubmed-91011922022-05-14 Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program Świtała, Katarzyna Bojarczuk, Aleksandra Hajto, Jacek Piechota, Marcin Buryta, Maciej Leońska-Duniec, Agata Int J Environ Res Public Health Article Dopamine receptor D2 gene (DRD2) polymorphisms have been associated with cognitive abilities, obesity, addictions, and physical-activity-related behaviors, which may underlie differences in the effectiveness of training programs. What is not yet clear is the impact of DRD2 polymorphisms on the effectiveness of exercise programs. Thus, the aim of this study was to investigate the association between the DRD2 polymorphic sites (rs1076560, rs12364283, rs1799732, rs1800497, and rs1800498) and the body’s response to regular physical activity. We studied genotypes and haplotypes distribution in a group of 165 females measured for body mass and body composition measurements, lipid profile, and glucose levels before and after realization of a 12-week training program. When tested individually, statistical analyses revealed one significant genotype by training interaction under the general model (for the basal metabolic rate, BMR, p = 0.033). Carriers of the rs1076560 CC genotype exhibited a decrease in BMR in response to training (p = 0.006). Haplotype analyses also showed that (i) the CACCC and CACTT haplotypes were associated with a post-training decrease in glucose level (β = −4.11, p = 0.032; β = −6.86, p = 0.020, respectively); (ii) the CGCCT with an increase in BMR (β = 0.65, p = 0.003) and fat free mass (FFM, β = 1.20, p = 0.009); (iii) the CA-CT with a decrease in low-density lipoprotein cholesterol (LDL, β = −17.26, p = 0.046). These results provide some evidence that the DRD2 polymorphisms may play a role in post-training changes in lipid and carbohydrate metabolism, and, as a consequence, in the effectiveness of training programs. MDPI 2022-04-19 /pmc/articles/PMC9101192/ /pubmed/35564336 http://dx.doi.org/10.3390/ijerph19094942 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Świtała, Katarzyna
Bojarczuk, Aleksandra
Hajto, Jacek
Piechota, Marcin
Buryta, Maciej
Leońska-Duniec, Agata
Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program
title Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program
title_full Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program
title_fullStr Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program
title_full_unstemmed Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program
title_short Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program
title_sort impact of the drd2 polymorphisms on the effectiveness of the training program
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101192/
https://www.ncbi.nlm.nih.gov/pubmed/35564336
http://dx.doi.org/10.3390/ijerph19094942
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