A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression

This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In...

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Detalles Bibliográficos
Autor principal: Cohen-Armon, Malka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101275/
https://www.ncbi.nlm.nih.gov/pubmed/35563882
http://dx.doi.org/10.3390/cells11091576
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author Cohen-Armon, Malka
author_facet Cohen-Armon, Malka
author_sort Cohen-Armon, Malka
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description This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.
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spelling pubmed-91012752022-05-14 A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression Cohen-Armon, Malka Cells Review This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation. MDPI 2022-05-07 /pmc/articles/PMC9101275/ /pubmed/35563882 http://dx.doi.org/10.3390/cells11091576 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cohen-Armon, Malka
A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression
title A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression
title_full A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression
title_fullStr A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression
title_full_unstemmed A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression
title_short A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression
title_sort long-lasting parp1-activation mediates signal-induced gene expression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101275/
https://www.ncbi.nlm.nih.gov/pubmed/35563882
http://dx.doi.org/10.3390/cells11091576
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