Cargando…
Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems
(1) Background: The aim of this study was to compare perinatal outcomes and complication rates of vesicoamniotic shunting (VAS) before 17 + 0 weeks in isolated LUTO (lower urinary tract obstruction) with the Somatex(®) intrauterine shunt vs. the Harrison fetal bladder shunt. (2) Methods: This is a r...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101314/ https://www.ncbi.nlm.nih.gov/pubmed/35566484 http://dx.doi.org/10.3390/jcm11092359 |
_version_ | 1784707055517433856 |
---|---|
author | Strizek, Brigitte Spicher, Theresa Gottschalk, Ingo Böckenhoff, Paul Simonini, Corinna Berg, Christoph Gembruch, Ulrich Geipel, Annegret |
author_facet | Strizek, Brigitte Spicher, Theresa Gottschalk, Ingo Böckenhoff, Paul Simonini, Corinna Berg, Christoph Gembruch, Ulrich Geipel, Annegret |
author_sort | Strizek, Brigitte |
collection | PubMed |
description | (1) Background: The aim of this study was to compare perinatal outcomes and complication rates of vesicoamniotic shunting (VAS) before 17 + 0 weeks in isolated LUTO (lower urinary tract obstruction) with the Somatex(®) intrauterine shunt vs. the Harrison fetal bladder shunt. (2) Methods: This is a retrospective cohort study in two tertiary fetal medicine centers. From 2004–2014, the Harrison fetal bladder shunt was used, and from late 2014–2017, the Somatex shunt. Obstetrics and pediatric charts were reviewed for complications, course of pregnancy, perinatal outcome, and postnatal renal function. (3) Results: Twenty-four fetuses underwent VAS with a Harrison (H) shunt and 33 fetuses with a Somatex (S) shunt. Live birth rates and survival to last follow-up were significantly higher in the Somatex group, at 84.8% and 81.8%, respectively, vs. 50% and 33.3% in the Harrison group (p = 0.007 and p < 0.001). The dislocation rate in the Somatex group (36.4%) was significantly lower than in the Harrison group (87.5%) (p < 0.001). The median time to dislocation was significantly different, at 20.6 days (H) vs. 73.9 days (S) (p = 0.002), as was gestational age at dislocation (17 (H) vs. 25 (S) weeks, p < 0.001). Renal function was normal in early childhood in 51% (S) vs. 29% (H) (p = 0.11). (4) Conclusions: VAS before 17 + 0 weeks gestational age with a Somatex shunt improves perinatal survival significantly and might even have a positive effect on renal function, probably due to the lower dislocation rates. A normal amount of amniotic fluid in the third trimester was the best predictor of normal renal function in early childhood. |
format | Online Article Text |
id | pubmed-9101314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91013142022-05-14 Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems Strizek, Brigitte Spicher, Theresa Gottschalk, Ingo Böckenhoff, Paul Simonini, Corinna Berg, Christoph Gembruch, Ulrich Geipel, Annegret J Clin Med Article (1) Background: The aim of this study was to compare perinatal outcomes and complication rates of vesicoamniotic shunting (VAS) before 17 + 0 weeks in isolated LUTO (lower urinary tract obstruction) with the Somatex(®) intrauterine shunt vs. the Harrison fetal bladder shunt. (2) Methods: This is a retrospective cohort study in two tertiary fetal medicine centers. From 2004–2014, the Harrison fetal bladder shunt was used, and from late 2014–2017, the Somatex shunt. Obstetrics and pediatric charts were reviewed for complications, course of pregnancy, perinatal outcome, and postnatal renal function. (3) Results: Twenty-four fetuses underwent VAS with a Harrison (H) shunt and 33 fetuses with a Somatex (S) shunt. Live birth rates and survival to last follow-up were significantly higher in the Somatex group, at 84.8% and 81.8%, respectively, vs. 50% and 33.3% in the Harrison group (p = 0.007 and p < 0.001). The dislocation rate in the Somatex group (36.4%) was significantly lower than in the Harrison group (87.5%) (p < 0.001). The median time to dislocation was significantly different, at 20.6 days (H) vs. 73.9 days (S) (p = 0.002), as was gestational age at dislocation (17 (H) vs. 25 (S) weeks, p < 0.001). Renal function was normal in early childhood in 51% (S) vs. 29% (H) (p = 0.11). (4) Conclusions: VAS before 17 + 0 weeks gestational age with a Somatex shunt improves perinatal survival significantly and might even have a positive effect on renal function, probably due to the lower dislocation rates. A normal amount of amniotic fluid in the third trimester was the best predictor of normal renal function in early childhood. MDPI 2022-04-22 /pmc/articles/PMC9101314/ /pubmed/35566484 http://dx.doi.org/10.3390/jcm11092359 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Strizek, Brigitte Spicher, Theresa Gottschalk, Ingo Böckenhoff, Paul Simonini, Corinna Berg, Christoph Gembruch, Ulrich Geipel, Annegret Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems |
title | Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems |
title_full | Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems |
title_fullStr | Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems |
title_full_unstemmed | Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems |
title_short | Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems |
title_sort | vesicoamniotic shunting before 17 + 0 weeks in fetuses with lower urinary tract obstruction (luto): comparison of somatex vs. harrison shunt systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101314/ https://www.ncbi.nlm.nih.gov/pubmed/35566484 http://dx.doi.org/10.3390/jcm11092359 |
work_keys_str_mv | AT strizekbrigitte vesicoamnioticshuntingbefore170weeksinfetuseswithlowerurinarytractobstructionlutocomparisonofsomatexvsharrisonshuntsystems AT spichertheresa vesicoamnioticshuntingbefore170weeksinfetuseswithlowerurinarytractobstructionlutocomparisonofsomatexvsharrisonshuntsystems AT gottschalkingo vesicoamnioticshuntingbefore170weeksinfetuseswithlowerurinarytractobstructionlutocomparisonofsomatexvsharrisonshuntsystems AT bockenhoffpaul vesicoamnioticshuntingbefore170weeksinfetuseswithlowerurinarytractobstructionlutocomparisonofsomatexvsharrisonshuntsystems AT simoninicorinna vesicoamnioticshuntingbefore170weeksinfetuseswithlowerurinarytractobstructionlutocomparisonofsomatexvsharrisonshuntsystems AT bergchristoph vesicoamnioticshuntingbefore170weeksinfetuseswithlowerurinarytractobstructionlutocomparisonofsomatexvsharrisonshuntsystems AT gembruchulrich vesicoamnioticshuntingbefore170weeksinfetuseswithlowerurinarytractobstructionlutocomparisonofsomatexvsharrisonshuntsystems AT geipelannegret vesicoamnioticshuntingbefore170weeksinfetuseswithlowerurinarytractobstructionlutocomparisonofsomatexvsharrisonshuntsystems |