Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years

Both humoral and cellular anamnestic responses are significant for protective immunity against SARS-CoV-2. In the current study, the responses in elderly people before and after a fourth vaccine dose of BNT162b2 were compared to those of individuals immunized with three vaccine doses. Although a boo...

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Detalles Bibliográficos
Autores principales: Bar-Haim, Erez, Eliakim-Raz, Noa, Stemmer, Amos, Cohen, Hila, Elia, Uri, Ness, Asaf, Awwad, Muhammad, Ghantous, Nassem, Moskovits, Neta, Rotem, Shahar, Stemmer, Salomon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101339/
https://www.ncbi.nlm.nih.gov/pubmed/35566774
http://dx.doi.org/10.3390/jcm11092649
Descripción
Sumario:Both humoral and cellular anamnestic responses are significant for protective immunity against SARS-CoV-2. In the current study, the responses in elderly people before and after a fourth vaccine dose of BNT162b2 were compared to those of individuals immunized with three vaccine doses. Although a boost effect was observed, the high response following the third administration questions the necessity of an early fourth boost.

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