Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years

Both humoral and cellular anamnestic responses are significant for protective immunity against SARS-CoV-2. In the current study, the responses in elderly people before and after a fourth vaccine dose of BNT162b2 were compared to those of individuals immunized with three vaccine doses. Although a boo...

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Autores principales: Bar-Haim, Erez, Eliakim-Raz, Noa, Stemmer, Amos, Cohen, Hila, Elia, Uri, Ness, Asaf, Awwad, Muhammad, Ghantous, Nassem, Moskovits, Neta, Rotem, Shahar, Stemmer, Salomon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101339/
https://www.ncbi.nlm.nih.gov/pubmed/35566774
http://dx.doi.org/10.3390/jcm11092649
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author Bar-Haim, Erez
Eliakim-Raz, Noa
Stemmer, Amos
Cohen, Hila
Elia, Uri
Ness, Asaf
Awwad, Muhammad
Ghantous, Nassem
Moskovits, Neta
Rotem, Shahar
Stemmer, Salomon M.
author_facet Bar-Haim, Erez
Eliakim-Raz, Noa
Stemmer, Amos
Cohen, Hila
Elia, Uri
Ness, Asaf
Awwad, Muhammad
Ghantous, Nassem
Moskovits, Neta
Rotem, Shahar
Stemmer, Salomon M.
author_sort Bar-Haim, Erez
collection PubMed
description Both humoral and cellular anamnestic responses are significant for protective immunity against SARS-CoV-2. In the current study, the responses in elderly people before and after a fourth vaccine dose of BNT162b2 were compared to those of individuals immunized with three vaccine doses. Although a boost effect was observed, the high response following the third administration questions the necessity of an early fourth boost.
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spelling pubmed-91013392022-05-14 Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years Bar-Haim, Erez Eliakim-Raz, Noa Stemmer, Amos Cohen, Hila Elia, Uri Ness, Asaf Awwad, Muhammad Ghantous, Nassem Moskovits, Neta Rotem, Shahar Stemmer, Salomon M. J Clin Med Brief Report Both humoral and cellular anamnestic responses are significant for protective immunity against SARS-CoV-2. In the current study, the responses in elderly people before and after a fourth vaccine dose of BNT162b2 were compared to those of individuals immunized with three vaccine doses. Although a boost effect was observed, the high response following the third administration questions the necessity of an early fourth boost. MDPI 2022-05-08 /pmc/articles/PMC9101339/ /pubmed/35566774 http://dx.doi.org/10.3390/jcm11092649 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Bar-Haim, Erez
Eliakim-Raz, Noa
Stemmer, Amos
Cohen, Hila
Elia, Uri
Ness, Asaf
Awwad, Muhammad
Ghantous, Nassem
Moskovits, Neta
Rotem, Shahar
Stemmer, Salomon M.
Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years
title Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years
title_full Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years
title_fullStr Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years
title_full_unstemmed Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years
title_short Humoral and T-Cell Response before and after a Fourth BNT162b2 Vaccine Dose in Adults ≥60 Years
title_sort humoral and t-cell response before and after a fourth bnt162b2 vaccine dose in adults ≥60 years
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101339/
https://www.ncbi.nlm.nih.gov/pubmed/35566774
http://dx.doi.org/10.3390/jcm11092649
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