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Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents

Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence of new viruses and subject to drug resistance...

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Autores principales: Tran, Tuyen N., Henary, Maged
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101374/
https://www.ncbi.nlm.nih.gov/pubmed/35566055
http://dx.doi.org/10.3390/molecules27092700
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author Tran, Tuyen N.
Henary, Maged
author_facet Tran, Tuyen N.
Henary, Maged
author_sort Tran, Tuyen N.
collection PubMed
description Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence of new viruses and subject to drug resistance. Nitrogen-containing heterocycles have compatible structures and properties with exceptional biological activity for the drug design of antiviral agents. They provided a broad spectrum of interference against viral infection at various stages, from blocking early viral entry to disrupting the viral genome replication process by targeting different enzymes and proteins of viruses. This review focused on the synthesis and application of antiviral agents derived from various nitrogen-containing heterocycles, such as indole, pyrrole, pyrimidine, pyrazole, and quinoline, within the last ten years. The synthesized scaffolds target HIV, HCV/HBV, VZV/HSV, SARS-CoV, COVID-19, and influenza viruses.
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spelling pubmed-91013742022-05-14 Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents Tran, Tuyen N. Henary, Maged Molecules Review Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence of new viruses and subject to drug resistance. Nitrogen-containing heterocycles have compatible structures and properties with exceptional biological activity for the drug design of antiviral agents. They provided a broad spectrum of interference against viral infection at various stages, from blocking early viral entry to disrupting the viral genome replication process by targeting different enzymes and proteins of viruses. This review focused on the synthesis and application of antiviral agents derived from various nitrogen-containing heterocycles, such as indole, pyrrole, pyrimidine, pyrazole, and quinoline, within the last ten years. The synthesized scaffolds target HIV, HCV/HBV, VZV/HSV, SARS-CoV, COVID-19, and influenza viruses. MDPI 2022-04-22 /pmc/articles/PMC9101374/ /pubmed/35566055 http://dx.doi.org/10.3390/molecules27092700 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tran, Tuyen N.
Henary, Maged
Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents
title Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents
title_full Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents
title_fullStr Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents
title_full_unstemmed Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents
title_short Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents
title_sort synthesis and applications of nitrogen-containing heterocycles as antiviral agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101374/
https://www.ncbi.nlm.nih.gov/pubmed/35566055
http://dx.doi.org/10.3390/molecules27092700
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