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Extrachromosomal Circular DNA from TCGA Tumors Is Generated from Common Genomic Loci, Is Characterized by Self-Homology and DNA Motifs near Circle Breakpoints

SIMPLE SUMMARY: Extrachromosomal circular DNA is ubiquitous in eukaryotic cells. In tumors, highly amplified oncogenes exist in circular DNA, and circular DNA correlates with poor prognosis in multiple tumor types. Despite the emerging importance of extrachromosomal circular DNA, little is known abo...

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Detalles Bibliográficos
Autores principales:	Tatman, Philip D., Black, Joshua C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101409/ https://www.ncbi.nlm.nih.gov/pubmed/35565439 http://dx.doi.org/10.3390/cancers14092310

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