Fighting the Huntington’s Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies

A set of guanine-rich aptamers able to preferentially recognize full-length huntingtin with an expanded polyglutamine tract has been recently identified, showing high efficacy in modulating the functions of the mutated protein in a variety of cell experiments. We here report a detailed biophysical c...

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Detalles Bibliográficos
Autores principales: Riccardi, Claudia, D’Aria, Federica, Digilio, Filomena Anna, Carillo, Maria Rosaria, Amato, Jussara, Fasano, Dominga, De Rosa, Laura, Paladino, Simona, Melone, Mariarosa Anna Beatrice, Montesarchio, Daniela, Giancola, Concetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101412/
https://www.ncbi.nlm.nih.gov/pubmed/35563194
http://dx.doi.org/10.3390/ijms23094804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101412/
https://www.ncbi.nlm.nih.gov/pubmed/35563194
http://dx.doi.org/10.3390/ijms23094804

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