Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs

At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions, nanoparticles, liposomes, etc.), salt format...

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Detalles Bibliográficos
Autores principales: Sharma, Arvind, Arora, Kanika, Mohapatra, Harapriya, Sindhu, Rakesh K., Bulzan, Madalin, Cavalu, Simona, Paneshar, Gulsheen, Elansary, Hosam O., El-Sabrout, Ahmed M., Mahmoud, Eman A., Alaklabi, Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101434/
https://www.ncbi.nlm.nih.gov/pubmed/35566319
http://dx.doi.org/10.3390/molecules27092969
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author Sharma, Arvind
Arora, Kanika
Mohapatra, Harapriya
Sindhu, Rakesh K.
Bulzan, Madalin
Cavalu, Simona
Paneshar, Gulsheen
Elansary, Hosam O.
El-Sabrout, Ahmed M.
Mahmoud, Eman A.
Alaklabi, Abdullah
author_facet Sharma, Arvind
Arora, Kanika
Mohapatra, Harapriya
Sindhu, Rakesh K.
Bulzan, Madalin
Cavalu, Simona
Paneshar, Gulsheen
Elansary, Hosam O.
El-Sabrout, Ahmed M.
Mahmoud, Eman A.
Alaklabi, Abdullah
author_sort Sharma, Arvind
collection PubMed
description At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions, nanoparticles, liposomes, etc.), salt formation, and many more. One promising avenue attaining attention presently is supersaturated drug delivery systems. When exposed to gastrointestinal fluids, drug concentration exceeds equilibrium solubility and a supersaturation state is maintained long enough to be absorbed, enhancing bioavailability. In this review, the latest developments in supersaturated drug delivery systems are addressed in depth.
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spelling pubmed-91014342022-05-14 Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs Sharma, Arvind Arora, Kanika Mohapatra, Harapriya Sindhu, Rakesh K. Bulzan, Madalin Cavalu, Simona Paneshar, Gulsheen Elansary, Hosam O. El-Sabrout, Ahmed M. Mahmoud, Eman A. Alaklabi, Abdullah Molecules Review At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions, nanoparticles, liposomes, etc.), salt formation, and many more. One promising avenue attaining attention presently is supersaturated drug delivery systems. When exposed to gastrointestinal fluids, drug concentration exceeds equilibrium solubility and a supersaturation state is maintained long enough to be absorbed, enhancing bioavailability. In this review, the latest developments in supersaturated drug delivery systems are addressed in depth. MDPI 2022-05-06 /pmc/articles/PMC9101434/ /pubmed/35566319 http://dx.doi.org/10.3390/molecules27092969 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sharma, Arvind
Arora, Kanika
Mohapatra, Harapriya
Sindhu, Rakesh K.
Bulzan, Madalin
Cavalu, Simona
Paneshar, Gulsheen
Elansary, Hosam O.
El-Sabrout, Ahmed M.
Mahmoud, Eman A.
Alaklabi, Abdullah
Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
title Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
title_full Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
title_fullStr Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
title_full_unstemmed Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
title_short Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
title_sort supersaturation-based drug delivery systems: strategy for bioavailability enhancement of poorly water-soluble drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101434/
https://www.ncbi.nlm.nih.gov/pubmed/35566319
http://dx.doi.org/10.3390/molecules27092969
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