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Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults

BACKGROUND: Age-related muscle mass and function decline are critical issues that have gained attention in clinical practice and research. Nevertheless, little is known regarding the time course of muscle health progression, and its determinants during this transition should be estimated. METHODS: W...

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Autores principales: Chao, Yuan-Ping, Fang, Wen-Hui, Chen, Wei-Liang, Peng, Tao-Chun, Yang, Wei-Shiung, Kao, Tung-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101463/
https://www.ncbi.nlm.nih.gov/pubmed/35571885
http://dx.doi.org/10.3389/fnut.2022.817044
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author Chao, Yuan-Ping
Fang, Wen-Hui
Chen, Wei-Liang
Peng, Tao-Chun
Yang, Wei-Shiung
Kao, Tung-Wei
author_facet Chao, Yuan-Ping
Fang, Wen-Hui
Chen, Wei-Liang
Peng, Tao-Chun
Yang, Wei-Shiung
Kao, Tung-Wei
author_sort Chao, Yuan-Ping
collection PubMed
description BACKGROUND: Age-related muscle mass and function decline are critical issues that have gained attention in clinical practice and research. Nevertheless, little is known regarding the time course of muscle health progression, and its determinants during this transition should be estimated. METHODS: We enrolled community-dwelling adults aged ≥65 years during their regular health checkup. The participants’ body composition and muscle function were measured annually from 2015 to 2021. Presarcopenia was characterized by the loss of muscle mass only; dynapenia was defined as low muscle function without changes in muscle mass; and sarcopenia was indicated as a decline in both muscle mass and muscle function. We observed the natural course of muscle health progression during aging. The relationship between muscle health decline and different determinants among old adults was examined. RESULTS: Among 568 participants, there was 18.49%, 3.52%, and 1.06% of healthy individuals transited to dynapenia, presarcopenia, and sarcopenia, respectively. Significant positive correlations between age, fat-to-muscle ratio (FMR) and the dynapenia transition were existed [hazard ratio (HR) = 1.08 and HR = 1.73, all p < 0.05]. Serum albumin level had negative correlation with the dynapenia transition risk (HR = 0.30, p = 0.004). Participants with these three risk factors had the highest HR of dynapenia transition compared to those without (HR = 8.67, p = 0.001). A dose-response effect existed between risk factors numbers and the risk of dynapenia transition (p for trend < 0.001). This positive association and dose-response relationship remains after multiple covariates adjustment (HR = 7.74, p = 0.002, p for trend < 0.001). Participants with two or more than two risk factors had a higher risk of dynapenia transition than those with low risk factors (p = 0.0027), and the HR was 1.96 after multiple covariate adjustment (p = 0.029). CONCLUSION: Healthy community-dwelling old adults tended to transit to dynapenia during muscle health deterioration. Individuals with older age, higher FMR, lower albumin level had a higher risk of dynapenia transition; and a positive dose-response effect existed among this population as well.
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spelling pubmed-91014632022-05-14 Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults Chao, Yuan-Ping Fang, Wen-Hui Chen, Wei-Liang Peng, Tao-Chun Yang, Wei-Shiung Kao, Tung-Wei Front Nutr Nutrition BACKGROUND: Age-related muscle mass and function decline are critical issues that have gained attention in clinical practice and research. Nevertheless, little is known regarding the time course of muscle health progression, and its determinants during this transition should be estimated. METHODS: We enrolled community-dwelling adults aged ≥65 years during their regular health checkup. The participants’ body composition and muscle function were measured annually from 2015 to 2021. Presarcopenia was characterized by the loss of muscle mass only; dynapenia was defined as low muscle function without changes in muscle mass; and sarcopenia was indicated as a decline in both muscle mass and muscle function. We observed the natural course of muscle health progression during aging. The relationship between muscle health decline and different determinants among old adults was examined. RESULTS: Among 568 participants, there was 18.49%, 3.52%, and 1.06% of healthy individuals transited to dynapenia, presarcopenia, and sarcopenia, respectively. Significant positive correlations between age, fat-to-muscle ratio (FMR) and the dynapenia transition were existed [hazard ratio (HR) = 1.08 and HR = 1.73, all p < 0.05]. Serum albumin level had negative correlation with the dynapenia transition risk (HR = 0.30, p = 0.004). Participants with these three risk factors had the highest HR of dynapenia transition compared to those without (HR = 8.67, p = 0.001). A dose-response effect existed between risk factors numbers and the risk of dynapenia transition (p for trend < 0.001). This positive association and dose-response relationship remains after multiple covariates adjustment (HR = 7.74, p = 0.002, p for trend < 0.001). Participants with two or more than two risk factors had a higher risk of dynapenia transition than those with low risk factors (p = 0.0027), and the HR was 1.96 after multiple covariate adjustment (p = 0.029). CONCLUSION: Healthy community-dwelling old adults tended to transit to dynapenia during muscle health deterioration. Individuals with older age, higher FMR, lower albumin level had a higher risk of dynapenia transition; and a positive dose-response effect existed among this population as well. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9101463/ /pubmed/35571885 http://dx.doi.org/10.3389/fnut.2022.817044 Text en Copyright © 2022 Chao, Fang, Chen, Peng, Yang and Kao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Chao, Yuan-Ping
Fang, Wen-Hui
Chen, Wei-Liang
Peng, Tao-Chun
Yang, Wei-Shiung
Kao, Tung-Wei
Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults
title Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults
title_full Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults
title_fullStr Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults
title_full_unstemmed Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults
title_short Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults
title_sort exploring muscle health deterioration and its determinants among community-dwelling older adults
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101463/
https://www.ncbi.nlm.nih.gov/pubmed/35571885
http://dx.doi.org/10.3389/fnut.2022.817044
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