Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity

Hyperoside is an active ingredient in plants, such as Hypericum monogynum in Hypericaceae, Crataegus pinnatifida in Rosaceae and Polygonum aviculare in Polygonaceae. Its pharmacologic effects include preventing cancer and protecting the brain, neurons, heart, kidneys, lung, blood vessels, bones, joi...

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Autores principales: Xu, Sijin, Chen, Shuaipeng, Xia, Wenxin, Sui, Hong, Fu, Xueyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101560/
https://www.ncbi.nlm.nih.gov/pubmed/35566359
http://dx.doi.org/10.3390/molecules27093009
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author Xu, Sijin
Chen, Shuaipeng
Xia, Wenxin
Sui, Hong
Fu, Xueyan
author_facet Xu, Sijin
Chen, Shuaipeng
Xia, Wenxin
Sui, Hong
Fu, Xueyan
author_sort Xu, Sijin
collection PubMed
description Hyperoside is an active ingredient in plants, such as Hypericum monogynum in Hypericaceae, Crataegus pinnatifida in Rosaceae and Polygonum aviculare in Polygonaceae. Its pharmacologic effects include preventing cancer and protecting the brain, neurons, heart, kidneys, lung, blood vessels, bones, joints and liver, among others. Pharmacokinetic analysis of hyperoside has revealed that it mainly accumulates in the kidney. However, long-term application of high-dose hyperoside should be avoided in clinical practice because of its renal toxicity. This review summarises the structure, synthesis, pharmacology, pharmacokinetics and toxicity of hyperoside.
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spelling pubmed-91015602022-05-14 Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity Xu, Sijin Chen, Shuaipeng Xia, Wenxin Sui, Hong Fu, Xueyan Molecules Review Hyperoside is an active ingredient in plants, such as Hypericum monogynum in Hypericaceae, Crataegus pinnatifida in Rosaceae and Polygonum aviculare in Polygonaceae. Its pharmacologic effects include preventing cancer and protecting the brain, neurons, heart, kidneys, lung, blood vessels, bones, joints and liver, among others. Pharmacokinetic analysis of hyperoside has revealed that it mainly accumulates in the kidney. However, long-term application of high-dose hyperoside should be avoided in clinical practice because of its renal toxicity. This review summarises the structure, synthesis, pharmacology, pharmacokinetics and toxicity of hyperoside. MDPI 2022-05-07 /pmc/articles/PMC9101560/ /pubmed/35566359 http://dx.doi.org/10.3390/molecules27093009 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Sijin
Chen, Shuaipeng
Xia, Wenxin
Sui, Hong
Fu, Xueyan
Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
title Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
title_full Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
title_fullStr Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
title_full_unstemmed Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
title_short Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
title_sort hyperoside: a review of its structure, synthesis, pharmacology, pharmacokinetics and toxicity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101560/
https://www.ncbi.nlm.nih.gov/pubmed/35566359
http://dx.doi.org/10.3390/molecules27093009
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