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Human Estrogen Receptor Alpha Antagonists, Part 3: 3-D Pharmacophore and 3-D QSAR Guided Brefeldin A Hit-to-Lead Optimization toward New Breast Cancer Suppressants

The estrogen receptor α (ERα) is an important biological target mediating 17β-estradiol driven breast cancer (BC) development. Aiming to develop innovative drugs against BC, either wild-type or mutated ligand-ERα complexes were used as source data to build structure-based 3-D pharmacophore and 3-D Q...

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Detalles Bibliográficos
Autores principales:	Kurtanović, Nezrina, Tomašević, Nevena, Matić, Sanja, Proia, Elenora, Sabatino, Manuela, Antonini, Lorenzo, Mladenović, Milan, Ragno, Rino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101642/ https://www.ncbi.nlm.nih.gov/pubmed/35566172 http://dx.doi.org/10.3390/molecules27092823

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