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Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters †
A series of novel conjugates of cobalt bis(dicarbollide) and closo-dodecaborate with curcumin were synthesized by copper(I)-catalyzed azide-alkyne cycloaddition. These conjugates were tested for antibacterial activity. It was shown that all derivatives are active when exposed to Bacillus cereus ATCC...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101702/ https://www.ncbi.nlm.nih.gov/pubmed/35566270 http://dx.doi.org/10.3390/molecules27092920 |
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author | Druzina, Anna A. Grammatikova, Natalia E. Zhidkova, Olga B. Nekrasova, Natalia A. Dudarova, Nadezhda V. Kosenko, Irina D. Grin, Mikhail A. Bregadze, Vladimir I. |
author_facet | Druzina, Anna A. Grammatikova, Natalia E. Zhidkova, Olga B. Nekrasova, Natalia A. Dudarova, Nadezhda V. Kosenko, Irina D. Grin, Mikhail A. Bregadze, Vladimir I. |
author_sort | Druzina, Anna A. |
collection | PubMed |
description | A series of novel conjugates of cobalt bis(dicarbollide) and closo-dodecaborate with curcumin were synthesized by copper(I)-catalyzed azide-alkyne cycloaddition. These conjugates were tested for antibacterial activity. It was shown that all derivatives are active when exposed to Bacillus cereus ATCC 10702 and are not active against Gram-negative microorganisms and Candida albicans at the maximum studied concentration of 1000 mg/L. The conjugate of alkynyl-curcumin with azide synthesized from the tetrahydropyran derivative of cobalt bis(dicarbollide) exhibited activity against Gram-positive microorganisms: Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and the clinical isolate MRSA 17, that surpassed curcumin by 2–4 times. |
format | Online Article Text |
id | pubmed-9101702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91017022022-05-14 Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters † Druzina, Anna A. Grammatikova, Natalia E. Zhidkova, Olga B. Nekrasova, Natalia A. Dudarova, Nadezhda V. Kosenko, Irina D. Grin, Mikhail A. Bregadze, Vladimir I. Molecules Article A series of novel conjugates of cobalt bis(dicarbollide) and closo-dodecaborate with curcumin were synthesized by copper(I)-catalyzed azide-alkyne cycloaddition. These conjugates were tested for antibacterial activity. It was shown that all derivatives are active when exposed to Bacillus cereus ATCC 10702 and are not active against Gram-negative microorganisms and Candida albicans at the maximum studied concentration of 1000 mg/L. The conjugate of alkynyl-curcumin with azide synthesized from the tetrahydropyran derivative of cobalt bis(dicarbollide) exhibited activity against Gram-positive microorganisms: Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and the clinical isolate MRSA 17, that surpassed curcumin by 2–4 times. MDPI 2022-05-03 /pmc/articles/PMC9101702/ /pubmed/35566270 http://dx.doi.org/10.3390/molecules27092920 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Druzina, Anna A. Grammatikova, Natalia E. Zhidkova, Olga B. Nekrasova, Natalia A. Dudarova, Nadezhda V. Kosenko, Irina D. Grin, Mikhail A. Bregadze, Vladimir I. Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters † |
title | Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters † |
title_full | Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters † |
title_fullStr | Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters † |
title_full_unstemmed | Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters † |
title_short | Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters † |
title_sort | synthesis and antibacterial activity studies of the conjugates of curcumin with closo-dodecaborate and cobalt bis(dicarbollide) boron clusters † |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101702/ https://www.ncbi.nlm.nih.gov/pubmed/35566270 http://dx.doi.org/10.3390/molecules27092920 |
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