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Temporal Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients between 2004 and 2019

Background: In the recent years, antithrombotic prophylaxis in patients with atrial fibrillation (AF) has changed significantly. The main aim of this study is to assess the temporal trends of antithrombotic therapy and identify factors predisposing oral anticoagulant (OAC) use in stroke prevention i...

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Autores principales: Gorczyca-Głowacka, Iwona, Bielecka, Bernadetta, Wałek, Paweł, Chrapek, Magdalena, Ciba-Stemplewska, Agnieszka, Jelonek, Olga, Kot, Anna, Czyżyk, Anna, Pióro, Maciej, Major, Agnieszka, Wożakowska-Kapłon, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101720/
https://www.ncbi.nlm.nih.gov/pubmed/35564979
http://dx.doi.org/10.3390/ijerph19095584
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author Gorczyca-Głowacka, Iwona
Bielecka, Bernadetta
Wałek, Paweł
Chrapek, Magdalena
Ciba-Stemplewska, Agnieszka
Jelonek, Olga
Kot, Anna
Czyżyk, Anna
Pióro, Maciej
Major, Agnieszka
Wożakowska-Kapłon, Beata
author_facet Gorczyca-Głowacka, Iwona
Bielecka, Bernadetta
Wałek, Paweł
Chrapek, Magdalena
Ciba-Stemplewska, Agnieszka
Jelonek, Olga
Kot, Anna
Czyżyk, Anna
Pióro, Maciej
Major, Agnieszka
Wożakowska-Kapłon, Beata
author_sort Gorczyca-Głowacka, Iwona
collection PubMed
description Background: In the recent years, antithrombotic prophylaxis in patients with atrial fibrillation (AF) has changed significantly. The main aim of this study is to assess the temporal trends of antithrombotic therapy and identify factors predisposing oral anticoagulant (OAC) use in stroke prevention in AF patients. Methods: The present study is a retrospective, observational, single-center study, which includes consecutively hospitalized patients in the reference cardiology center from January 2004 to December 2019. Results: A total of 9656 patients (43.7% female, mean age 71.2 years) with AF between 2004–2019 are included. Among the total study population, in most of the patients (81.1%), OAC therapy was used, antiplatelet (APT) therapy was prescribed for 13.5% patients, heparins for 2.1% patients and 3.3% of patients did not receive any stroke prevention. OAC prescription significantly increased from 61.6% in 2004 to 97.4% in 2019. The independent predictors of OAC prescription were: the period of hospitalization, non-paroxysmal AF, age, hypertension, diabetes mellitus, previous thromboembolism, hospitalization due to electrical cardioversion, ablation or AF without any procedures. Conclusions: In hospitalized patients with AF, during sixteen years of the study period, a significant increase in OAC use and a decrease in APT use were noted. Factors other than these included in the CHA(2)DS(2)-VASc score were independent predictors of OAC use.
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spelling pubmed-91017202022-05-14 Temporal Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients between 2004 and 2019 Gorczyca-Głowacka, Iwona Bielecka, Bernadetta Wałek, Paweł Chrapek, Magdalena Ciba-Stemplewska, Agnieszka Jelonek, Olga Kot, Anna Czyżyk, Anna Pióro, Maciej Major, Agnieszka Wożakowska-Kapłon, Beata Int J Environ Res Public Health Article Background: In the recent years, antithrombotic prophylaxis in patients with atrial fibrillation (AF) has changed significantly. The main aim of this study is to assess the temporal trends of antithrombotic therapy and identify factors predisposing oral anticoagulant (OAC) use in stroke prevention in AF patients. Methods: The present study is a retrospective, observational, single-center study, which includes consecutively hospitalized patients in the reference cardiology center from January 2004 to December 2019. Results: A total of 9656 patients (43.7% female, mean age 71.2 years) with AF between 2004–2019 are included. Among the total study population, in most of the patients (81.1%), OAC therapy was used, antiplatelet (APT) therapy was prescribed for 13.5% patients, heparins for 2.1% patients and 3.3% of patients did not receive any stroke prevention. OAC prescription significantly increased from 61.6% in 2004 to 97.4% in 2019. The independent predictors of OAC prescription were: the period of hospitalization, non-paroxysmal AF, age, hypertension, diabetes mellitus, previous thromboembolism, hospitalization due to electrical cardioversion, ablation or AF without any procedures. Conclusions: In hospitalized patients with AF, during sixteen years of the study period, a significant increase in OAC use and a decrease in APT use were noted. Factors other than these included in the CHA(2)DS(2)-VASc score were independent predictors of OAC use. MDPI 2022-05-04 /pmc/articles/PMC9101720/ /pubmed/35564979 http://dx.doi.org/10.3390/ijerph19095584 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gorczyca-Głowacka, Iwona
Bielecka, Bernadetta
Wałek, Paweł
Chrapek, Magdalena
Ciba-Stemplewska, Agnieszka
Jelonek, Olga
Kot, Anna
Czyżyk, Anna
Pióro, Maciej
Major, Agnieszka
Wożakowska-Kapłon, Beata
Temporal Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients between 2004 and 2019
title Temporal Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients between 2004 and 2019
title_full Temporal Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients between 2004 and 2019
title_fullStr Temporal Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients between 2004 and 2019
title_full_unstemmed Temporal Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients between 2004 and 2019
title_short Temporal Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients between 2004 and 2019
title_sort temporal trends in oral anticoagulant prescription in atrial fibrillation patients between 2004 and 2019
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101720/
https://www.ncbi.nlm.nih.gov/pubmed/35564979
http://dx.doi.org/10.3390/ijerph19095584
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