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The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis provides a synthesis of the available evidence for the effects of interventions on outcome measures associated with sarcopenia in end-stage kidney disease (ESKD). Thirteen databases were searched, supplemented with internet and hand searching. Randomised cont...

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Autores principales: March, Daniel S., Wilkinson, Thomas J., Burnell, Thomas, Billany, Roseanne E., Jackson, Katherine, Baker, Luke A., Thomas, Amal, Robinson, Katherine A., Watson, Emma L., Graham-Brown, Matthew P. M., Jones, Arwel W., Burton, James O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101978/
https://www.ncbi.nlm.nih.gov/pubmed/35565785
http://dx.doi.org/10.3390/nu14091817
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author March, Daniel S.
Wilkinson, Thomas J.
Burnell, Thomas
Billany, Roseanne E.
Jackson, Katherine
Baker, Luke A.
Thomas, Amal
Robinson, Katherine A.
Watson, Emma L.
Graham-Brown, Matthew P. M.
Jones, Arwel W.
Burton, James O.
author_facet March, Daniel S.
Wilkinson, Thomas J.
Burnell, Thomas
Billany, Roseanne E.
Jackson, Katherine
Baker, Luke A.
Thomas, Amal
Robinson, Katherine A.
Watson, Emma L.
Graham-Brown, Matthew P. M.
Jones, Arwel W.
Burton, James O.
author_sort March, Daniel S.
collection PubMed
description This systematic review and meta-analysis provides a synthesis of the available evidence for the effects of interventions on outcome measures associated with sarcopenia in end-stage kidney disease (ESKD). Thirteen databases were searched, supplemented with internet and hand searching. Randomised controlled trials of non-pharmacological or pharmacological interventions in adults with ESKD were eligible. Trials were restricted to those which had reported measures of sarcopenia. Primary outcome measures were hand grip strength and sit-to-stand tests. Sixty-four trials were eligible (with nineteen being included in meta-analyses). Synthesised data indicated that intradialytic exercise increased hand grip strength (standardised mean difference, 0.58; 0.24 to 0.91; p = 0.0007; I(2) = 40%), and sit-to-stand (STS) 60 score (mean difference, 3.74 repetitions; 2.35 to 5.14; p < 0.001; I(2) = 0%). Intradialytic exercise alone, and protein supplementation alone, resulted in no statistically significant change in STS5 (−0.78 s; −1.86 to 0.30; p = 0.16; I(2) = 0%), and STS30 (MD, 0.97 repetitions; −0.16 to 2.10; p = 0.09; I(2) = 0%) performance, respectively. For secondary outcomes, L-carnitine and nandrolone-decanoate resulted in significant increases in muscle quantity in the dialysis population. Intradialytic exercise modifies measures of sarcopenia in the haemodialysis population; however, the majority of trials were low in quality. There is limited evidence for efficacious interventions in the peritoneal dialysis and transplant recipient populations.
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spelling pubmed-91019782022-05-14 The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis March, Daniel S. Wilkinson, Thomas J. Burnell, Thomas Billany, Roseanne E. Jackson, Katherine Baker, Luke A. Thomas, Amal Robinson, Katherine A. Watson, Emma L. Graham-Brown, Matthew P. M. Jones, Arwel W. Burton, James O. Nutrients Systematic Review This systematic review and meta-analysis provides a synthesis of the available evidence for the effects of interventions on outcome measures associated with sarcopenia in end-stage kidney disease (ESKD). Thirteen databases were searched, supplemented with internet and hand searching. Randomised controlled trials of non-pharmacological or pharmacological interventions in adults with ESKD were eligible. Trials were restricted to those which had reported measures of sarcopenia. Primary outcome measures were hand grip strength and sit-to-stand tests. Sixty-four trials were eligible (with nineteen being included in meta-analyses). Synthesised data indicated that intradialytic exercise increased hand grip strength (standardised mean difference, 0.58; 0.24 to 0.91; p = 0.0007; I(2) = 40%), and sit-to-stand (STS) 60 score (mean difference, 3.74 repetitions; 2.35 to 5.14; p < 0.001; I(2) = 0%). Intradialytic exercise alone, and protein supplementation alone, resulted in no statistically significant change in STS5 (−0.78 s; −1.86 to 0.30; p = 0.16; I(2) = 0%), and STS30 (MD, 0.97 repetitions; −0.16 to 2.10; p = 0.09; I(2) = 0%) performance, respectively. For secondary outcomes, L-carnitine and nandrolone-decanoate resulted in significant increases in muscle quantity in the dialysis population. Intradialytic exercise modifies measures of sarcopenia in the haemodialysis population; however, the majority of trials were low in quality. There is limited evidence for efficacious interventions in the peritoneal dialysis and transplant recipient populations. MDPI 2022-04-27 /pmc/articles/PMC9101978/ /pubmed/35565785 http://dx.doi.org/10.3390/nu14091817 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
March, Daniel S.
Wilkinson, Thomas J.
Burnell, Thomas
Billany, Roseanne E.
Jackson, Katherine
Baker, Luke A.
Thomas, Amal
Robinson, Katherine A.
Watson, Emma L.
Graham-Brown, Matthew P. M.
Jones, Arwel W.
Burton, James O.
The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis
title The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis
title_full The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis
title_fullStr The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis
title_full_unstemmed The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis
title_short The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis
title_sort effect of non-pharmacological and pharmacological interventions on measures associated with sarcopenia in end-stage kidney disease: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101978/
https://www.ncbi.nlm.nih.gov/pubmed/35565785
http://dx.doi.org/10.3390/nu14091817
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