Positive and Negative Regulators of Sclerostin Expression

Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation. Sclerostin plays an important role in the preservation of bone mass by functioning as a negativ...

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Detalles Bibliográficos
Autores principales: Iwamoto, Rina, Koide, Masanori, Udagawa, Nobuyuki, Kobayashi, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102037/
https://www.ncbi.nlm.nih.gov/pubmed/35563281
http://dx.doi.org/10.3390/ijms23094895
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author Iwamoto, Rina
Koide, Masanori
Udagawa, Nobuyuki
Kobayashi, Yasuhiro
author_facet Iwamoto, Rina
Koide, Masanori
Udagawa, Nobuyuki
Kobayashi, Yasuhiro
author_sort Iwamoto, Rina
collection PubMed
description Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation. Sclerostin plays an important role in the preservation of bone mass by functioning as a negative regulator of bone formation. A sclerostin deficiency causes sclerosteosis, which is characterized by an excess bone mass with enhanced bone formation in humans and mice. The expression of sclerostin is positively and negatively regulated by many factors, which also govern bone metabolism. Positive and negative regulators of sclerostin expression and their effects are introduced and discussed herein based on recent and previous findings, including our research.
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spelling pubmed-91020372022-05-14 Positive and Negative Regulators of Sclerostin Expression Iwamoto, Rina Koide, Masanori Udagawa, Nobuyuki Kobayashi, Yasuhiro Int J Mol Sci Review Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation. Sclerostin plays an important role in the preservation of bone mass by functioning as a negative regulator of bone formation. A sclerostin deficiency causes sclerosteosis, which is characterized by an excess bone mass with enhanced bone formation in humans and mice. The expression of sclerostin is positively and negatively regulated by many factors, which also govern bone metabolism. Positive and negative regulators of sclerostin expression and their effects are introduced and discussed herein based on recent and previous findings, including our research. MDPI 2022-04-28 /pmc/articles/PMC9102037/ /pubmed/35563281 http://dx.doi.org/10.3390/ijms23094895 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Iwamoto, Rina
Koide, Masanori
Udagawa, Nobuyuki
Kobayashi, Yasuhiro
Positive and Negative Regulators of Sclerostin Expression
title Positive and Negative Regulators of Sclerostin Expression
title_full Positive and Negative Regulators of Sclerostin Expression
title_fullStr Positive and Negative Regulators of Sclerostin Expression
title_full_unstemmed Positive and Negative Regulators of Sclerostin Expression
title_short Positive and Negative Regulators of Sclerostin Expression
title_sort positive and negative regulators of sclerostin expression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102037/
https://www.ncbi.nlm.nih.gov/pubmed/35563281
http://dx.doi.org/10.3390/ijms23094895
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