Changes in TSH, T4, T3 and Thyroglobulin Levels throughout Total Thyroidectomy

Introduction: To assess the impact of total thyroidectomy on thyroid function. Methods: Monocentric observational prospective study. Patients who benefited from a total thyroidectomy in the Department of Otolaryngology-Head and Neck Surgery between September 2017 and July 2019 were included. Three blood samples were taken from each patient during the perioperative period: preoperatively (T(0)), intraoperatively (T(1)), and postoperatively (T(2)). Changes in TSH, T4, T3, and thyroglobulin levels were evaluated from T(0) to T(2). Epidemiological data were retrieved from the medical charts. Statistical analyses were performed for the entire cohort and subgroups regarding preoperative treatment and type of disease. Results: Seventy-seven patients were included in the study. T4 and thyroglobulin levels increased significantly from T(0) to T(1). TSH, T4, T3, and thyroglobulin levels decreased significantly from T(1) to T(2). Conclusions: Our study confirmed the hypothesis of variable kinetics of thyroid hormone levels associated with the manipulation of the thyroid gland during surgery, but none of these changes resulted in clinical effects, including thyrotoxicosis.