Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells

We examined whether sulfated hyaluronan exerts inhibitory effects on enzymatic and biological actions of heparanase, a sole endo-beta-glucuronidase implicated in cancer malignancy and inflammation. Degradation of heparan sulfate by human and mouse heparanase was inhibited by sulfated hyaluronan. In...

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Detalles Bibliográficos
Autores principales: Shi, Jia, Kanoya, Riku, Tani, Yurina, Ishikawa, Sodai, Maeda, Rino, Suzuki, Sana, Kawanami, Fumiya, Miyagawa, Naoko, Takahashi, Katsuhiko, Oku, Teruaki, Yamamoto, Ami, Fukuzawa, Kaori, Nakajima, Motowo, Irimura, Tatsuro, Higashi, Nobuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102160/
https://www.ncbi.nlm.nih.gov/pubmed/35563446
http://dx.doi.org/10.3390/ijms23095055

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