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Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective observational study

OBJECTIVE: Establish whether the reliable measurement of cardiac time intervals of the fetal ECG can be automated and to address whether this approach could be used to investigate large datasets. DESIGN: Retrospective observational study. SETTING: Teaching hospitals in London UK, Nottingham UK and N...

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Autores principales: Chivers, SC, Vasavan, T, Nandi, M, Hayes-Gill, BR, Jayawardane, IA, Simpson, JM, Williamson, C, Fifer, WP, Lucchini, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102181/
https://www.ncbi.nlm.nih.gov/pubmed/35574238
http://dx.doi.org/10.1177/20480040221096209
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author Chivers, SC
Vasavan, T
Nandi, M
Hayes-Gill, BR
Jayawardane, IA
Simpson, JM
Williamson, C
Fifer, WP
Lucchini, M
author_facet Chivers, SC
Vasavan, T
Nandi, M
Hayes-Gill, BR
Jayawardane, IA
Simpson, JM
Williamson, C
Fifer, WP
Lucchini, M
author_sort Chivers, SC
collection PubMed
description OBJECTIVE: Establish whether the reliable measurement of cardiac time intervals of the fetal ECG can be automated and to address whether this approach could be used to investigate large datasets. DESIGN: Retrospective observational study. SETTING: Teaching hospitals in London UK, Nottingham UK and New York USA. PARTICIPANTS: Singleton pregnancies with no known fetal abnormality. METHODS: Archived fetal ECG's performed using the MonicaAN24 monitor. A single ECG (PQRST) complex was generated from 5000 signal-averaged beats and electrical cardiac time intervals measured in an automated way and manually. MAIN OUTCOME MEASURE: Validation of a newly developed algorithm to measure the cardiac time intervals of the fetal ECG. RESULTS: 188/236 (79.7%) subjects with fECGs of suitable signal:noise ratio were included for analysis comparing manual with automated measurement. PR interval was measured in 173/188 (92%), QRS complex in 170/188 (90%) and QT interval in 123/188 (65.4%). PR interval was 107.6 (12.07) ms [mean(SD)] manual vs 109.11 (14.7) ms algorithm. QRS duration was 54.72(6.35) ms manual vs 58.34(5.73) ms algorithm. QT-interval was 268.93 (21.59) ms manual vs 261.63 (36.16) ms algorithm. QTc was 407.5(32.71) ms manual vs 396.4 (54.78) ms algorithm. The QRS-duration increased with gestational age in both manual and algorithm measurements. CONCLUSION: Accurate measurement of fetal ECG cardiac time intervals can be automated with potential application to interpretation of larger datasets.
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spelling pubmed-91021812022-05-14 Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective observational study Chivers, SC Vasavan, T Nandi, M Hayes-Gill, BR Jayawardane, IA Simpson, JM Williamson, C Fifer, WP Lucchini, M JRSM Cardiovasc Dis Applications of waveform analysis in cardiovascular disease – Original Research Article OBJECTIVE: Establish whether the reliable measurement of cardiac time intervals of the fetal ECG can be automated and to address whether this approach could be used to investigate large datasets. DESIGN: Retrospective observational study. SETTING: Teaching hospitals in London UK, Nottingham UK and New York USA. PARTICIPANTS: Singleton pregnancies with no known fetal abnormality. METHODS: Archived fetal ECG's performed using the MonicaAN24 monitor. A single ECG (PQRST) complex was generated from 5000 signal-averaged beats and electrical cardiac time intervals measured in an automated way and manually. MAIN OUTCOME MEASURE: Validation of a newly developed algorithm to measure the cardiac time intervals of the fetal ECG. RESULTS: 188/236 (79.7%) subjects with fECGs of suitable signal:noise ratio were included for analysis comparing manual with automated measurement. PR interval was measured in 173/188 (92%), QRS complex in 170/188 (90%) and QT interval in 123/188 (65.4%). PR interval was 107.6 (12.07) ms [mean(SD)] manual vs 109.11 (14.7) ms algorithm. QRS duration was 54.72(6.35) ms manual vs 58.34(5.73) ms algorithm. QT-interval was 268.93 (21.59) ms manual vs 261.63 (36.16) ms algorithm. QTc was 407.5(32.71) ms manual vs 396.4 (54.78) ms algorithm. The QRS-duration increased with gestational age in both manual and algorithm measurements. CONCLUSION: Accurate measurement of fetal ECG cardiac time intervals can be automated with potential application to interpretation of larger datasets. SAGE Publications 2022-05-11 /pmc/articles/PMC9102181/ /pubmed/35574238 http://dx.doi.org/10.1177/20480040221096209 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Applications of waveform analysis in cardiovascular disease – Original Research Article
Chivers, SC
Vasavan, T
Nandi, M
Hayes-Gill, BR
Jayawardane, IA
Simpson, JM
Williamson, C
Fifer, WP
Lucchini, M
Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective observational study
title Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective observational study
title_full Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective observational study
title_fullStr Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective observational study
title_full_unstemmed Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective observational study
title_short Measurement of the cardiac time intervals of the fetal ECG utilising a computerised algorithm: A retrospective observational study
title_sort measurement of the cardiac time intervals of the fetal ecg utilising a computerised algorithm: a retrospective observational study
topic Applications of waveform analysis in cardiovascular disease – Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102181/
https://www.ncbi.nlm.nih.gov/pubmed/35574238
http://dx.doi.org/10.1177/20480040221096209
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