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The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia

Impairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological sympt...

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Autores principales: Rek-Owodziń, Katarzyna, Tyburski, Ernest, Plichta, Piotr, Waszczuk, Katarzyna, Bielecki, Maksymilian, Wietrzyński, Krzysztof, Podwalski, Piotr, Rudkowski, Krzysztof, Michalczyk, Anna, Grąźlewski, Tomasz, Sagan, Leszek, Kucharska-Mazur, Jolanta, Samochowiec, Jerzy, Mak, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102246/
https://www.ncbi.nlm.nih.gov/pubmed/35566742
http://dx.doi.org/10.3390/jcm11092619
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author Rek-Owodziń, Katarzyna
Tyburski, Ernest
Plichta, Piotr
Waszczuk, Katarzyna
Bielecki, Maksymilian
Wietrzyński, Krzysztof
Podwalski, Piotr
Rudkowski, Krzysztof
Michalczyk, Anna
Grąźlewski, Tomasz
Sagan, Leszek
Kucharska-Mazur, Jolanta
Samochowiec, Jerzy
Mak, Monika
author_facet Rek-Owodziń, Katarzyna
Tyburski, Ernest
Plichta, Piotr
Waszczuk, Katarzyna
Bielecki, Maksymilian
Wietrzyński, Krzysztof
Podwalski, Piotr
Rudkowski, Krzysztof
Michalczyk, Anna
Grąźlewski, Tomasz
Sagan, Leszek
Kucharska-Mazur, Jolanta
Samochowiec, Jerzy
Mak, Monika
author_sort Rek-Owodziń, Katarzyna
collection PubMed
description Impairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological symptoms and cognitive functions. We recruited 32 patients with first-episode psychosis (FEP), 70 with chronic schizophrenia (CS), and 39 healthy controls (HC). Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) and cognitive functions were measured with the MATRICS Cognitive Consensus Battery (MCCB). Cognitive deficits were present in both FEP and CS participants. CS individuals had lower overall scores and poorer working memory; however, clinical variables appeared to play a significant role in these scores. In FEP, disorganization correlated negatively with verbal and visual learning and memory, social cognition, and overall score; negative symptoms negatively correlated with social cognition. In CS participants, disorganization correlated negatively with speed of processing, reasoning, problem solving, and overall score; negative symptoms were negatively correlated with speed of processing, visual learning, memory, and overall score; positive symptoms were negatively correlated with reasoning and problem solving. Our findings indicate that psychopathological symptoms have a significant impact on cognitive functions in FEP and CS patients.
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spelling pubmed-91022462022-05-14 The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia Rek-Owodziń, Katarzyna Tyburski, Ernest Plichta, Piotr Waszczuk, Katarzyna Bielecki, Maksymilian Wietrzyński, Krzysztof Podwalski, Piotr Rudkowski, Krzysztof Michalczyk, Anna Grąźlewski, Tomasz Sagan, Leszek Kucharska-Mazur, Jolanta Samochowiec, Jerzy Mak, Monika J Clin Med Article Impairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological symptoms and cognitive functions. We recruited 32 patients with first-episode psychosis (FEP), 70 with chronic schizophrenia (CS), and 39 healthy controls (HC). Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) and cognitive functions were measured with the MATRICS Cognitive Consensus Battery (MCCB). Cognitive deficits were present in both FEP and CS participants. CS individuals had lower overall scores and poorer working memory; however, clinical variables appeared to play a significant role in these scores. In FEP, disorganization correlated negatively with verbal and visual learning and memory, social cognition, and overall score; negative symptoms negatively correlated with social cognition. In CS participants, disorganization correlated negatively with speed of processing, reasoning, problem solving, and overall score; negative symptoms were negatively correlated with speed of processing, visual learning, memory, and overall score; positive symptoms were negatively correlated with reasoning and problem solving. Our findings indicate that psychopathological symptoms have a significant impact on cognitive functions in FEP and CS patients. MDPI 2022-05-06 /pmc/articles/PMC9102246/ /pubmed/35566742 http://dx.doi.org/10.3390/jcm11092619 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rek-Owodziń, Katarzyna
Tyburski, Ernest
Plichta, Piotr
Waszczuk, Katarzyna
Bielecki, Maksymilian
Wietrzyński, Krzysztof
Podwalski, Piotr
Rudkowski, Krzysztof
Michalczyk, Anna
Grąźlewski, Tomasz
Sagan, Leszek
Kucharska-Mazur, Jolanta
Samochowiec, Jerzy
Mak, Monika
The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia
title The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia
title_full The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia
title_fullStr The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia
title_full_unstemmed The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia
title_short The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia
title_sort relationship between cognitive functions and psychopathological symptoms in first episode psychosis and chronic schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102246/
https://www.ncbi.nlm.nih.gov/pubmed/35566742
http://dx.doi.org/10.3390/jcm11092619
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