Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns †

Nucleosomes are basic units of DNA packing in eukaryotes. Their structure is well conserved from yeast to human and consists of the histone octamer core and 147 bp DNA wrapped around it. Nucleosomes are bound to a majority of the eukaryotic genomic DNA, including its regulatory regions. Hence, they...

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Autores principales: Pranckeviciene, Erinija, Hosid, Sergey, Maziukas, Indiras, Ioshikhes, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102330/
https://www.ncbi.nlm.nih.gov/pubmed/35563261
http://dx.doi.org/10.3390/ijms23094869
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author Pranckeviciene, Erinija
Hosid, Sergey
Maziukas, Indiras
Ioshikhes, Ilya
author_facet Pranckeviciene, Erinija
Hosid, Sergey
Maziukas, Indiras
Ioshikhes, Ilya
author_sort Pranckeviciene, Erinija
collection PubMed
description Nucleosomes are basic units of DNA packing in eukaryotes. Their structure is well conserved from yeast to human and consists of the histone octamer core and 147 bp DNA wrapped around it. Nucleosomes are bound to a majority of the eukaryotic genomic DNA, including its regulatory regions. Hence, they also play a major role in gene regulation. For the latter, their precise positioning on DNA is essential. In the present paper, we describe Galaxy dnpatterntools—software package for nucleosome DNA sequence analysis and mapping. This software will be useful for computational biologists practitioners to conduct more profound studies of gene regulatory mechanisms.
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spelling pubmed-91023302022-05-14 Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns † Pranckeviciene, Erinija Hosid, Sergey Maziukas, Indiras Ioshikhes, Ilya Int J Mol Sci Article Nucleosomes are basic units of DNA packing in eukaryotes. Their structure is well conserved from yeast to human and consists of the histone octamer core and 147 bp DNA wrapped around it. Nucleosomes are bound to a majority of the eukaryotic genomic DNA, including its regulatory regions. Hence, they also play a major role in gene regulation. For the latter, their precise positioning on DNA is essential. In the present paper, we describe Galaxy dnpatterntools—software package for nucleosome DNA sequence analysis and mapping. This software will be useful for computational biologists practitioners to conduct more profound studies of gene regulatory mechanisms. MDPI 2022-04-28 /pmc/articles/PMC9102330/ /pubmed/35563261 http://dx.doi.org/10.3390/ijms23094869 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pranckeviciene, Erinija
Hosid, Sergey
Maziukas, Indiras
Ioshikhes, Ilya
Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns †
title Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns †
title_full Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns †
title_fullStr Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns †
title_full_unstemmed Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns †
title_short Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns †
title_sort galaxy dnpatterntools for computational analysis of nucleosome positioning sequence patterns †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102330/
https://www.ncbi.nlm.nih.gov/pubmed/35563261
http://dx.doi.org/10.3390/ijms23094869
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