Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms

Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demo...

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Detalles Bibliográficos
Autores principales: Shurpik, Dmitriy N., Aleksandrova, Yulia I., Mostovaya, Olga A., Nazmutdinova, Viktoriya A., Tazieva, Regina E., Murzakhanov, Fadis F., Gafurov, Marat R., Zelenikhin, Pavel V., Subakaeva, Evgenia V., Sokolova, Evgenia A., Gerasimov, Alexander V., Gorodov, Vadim V., Islamov, Daut R., Cragg, Peter J., Stoikov, Ivan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102331/
https://www.ncbi.nlm.nih.gov/pubmed/35564312
http://dx.doi.org/10.3390/nano12091604
Descripción
Sumario:Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.

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