Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms

Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demo...

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Autores principales: Shurpik, Dmitriy N., Aleksandrova, Yulia I., Mostovaya, Olga A., Nazmutdinova, Viktoriya A., Tazieva, Regina E., Murzakhanov, Fadis F., Gafurov, Marat R., Zelenikhin, Pavel V., Subakaeva, Evgenia V., Sokolova, Evgenia A., Gerasimov, Alexander V., Gorodov, Vadim V., Islamov, Daut R., Cragg, Peter J., Stoikov, Ivan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102331/
https://www.ncbi.nlm.nih.gov/pubmed/35564312
http://dx.doi.org/10.3390/nano12091604
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author Shurpik, Dmitriy N.
Aleksandrova, Yulia I.
Mostovaya, Olga A.
Nazmutdinova, Viktoriya A.
Tazieva, Regina E.
Murzakhanov, Fadis F.
Gafurov, Marat R.
Zelenikhin, Pavel V.
Subakaeva, Evgenia V.
Sokolova, Evgenia A.
Gerasimov, Alexander V.
Gorodov, Vadim V.
Islamov, Daut R.
Cragg, Peter J.
Stoikov, Ivan I.
author_facet Shurpik, Dmitriy N.
Aleksandrova, Yulia I.
Mostovaya, Olga A.
Nazmutdinova, Viktoriya A.
Tazieva, Regina E.
Murzakhanov, Fadis F.
Gafurov, Marat R.
Zelenikhin, Pavel V.
Subakaeva, Evgenia V.
Sokolova, Evgenia A.
Gerasimov, Alexander V.
Gorodov, Vadim V.
Islamov, Daut R.
Cragg, Peter J.
Stoikov, Ivan I.
author_sort Shurpik, Dmitriy N.
collection PubMed
description Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.
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spelling pubmed-91023312022-05-14 Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms Shurpik, Dmitriy N. Aleksandrova, Yulia I. Mostovaya, Olga A. Nazmutdinova, Viktoriya A. Tazieva, Regina E. Murzakhanov, Fadis F. Gafurov, Marat R. Zelenikhin, Pavel V. Subakaeva, Evgenia V. Sokolova, Evgenia A. Gerasimov, Alexander V. Gorodov, Vadim V. Islamov, Daut R. Cragg, Peter J. Stoikov, Ivan I. Nanomaterials (Basel) Article Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces. MDPI 2022-05-09 /pmc/articles/PMC9102331/ /pubmed/35564312 http://dx.doi.org/10.3390/nano12091604 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shurpik, Dmitriy N.
Aleksandrova, Yulia I.
Mostovaya, Olga A.
Nazmutdinova, Viktoriya A.
Tazieva, Regina E.
Murzakhanov, Fadis F.
Gafurov, Marat R.
Zelenikhin, Pavel V.
Subakaeva, Evgenia V.
Sokolova, Evgenia A.
Gerasimov, Alexander V.
Gorodov, Vadim V.
Islamov, Daut R.
Cragg, Peter J.
Stoikov, Ivan I.
Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms
title Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms
title_full Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms
title_fullStr Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms
title_full_unstemmed Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms
title_short Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms
title_sort self-healing thiolated pillar[5]arene films containing moxifloxacin suppress the development of bacterial biofilms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102331/
https://www.ncbi.nlm.nih.gov/pubmed/35564312
http://dx.doi.org/10.3390/nano12091604
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