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Metabolite Identification of a Novel Anti-Leishmanial Agent OJT007 in Rat Liver Microsomes Using LC-MS/MS

The purpose of this study was to identify potential metabolic pathways and metabolites of OJT007, a methionine aminopeptidase 1 (MetAP1) inhibitor. OJT007 is a novel drug with potent antiproliferative effects against Leishmania Major. We conducted in vitro Phase I oxidation and Phase II glucuronidat...

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Detalles Bibliográficos
Autores principales:	Rincon Nigro, Maria Eugenia, Du, Ting, Gao, Song, Kaur, Manvir, Xie, Huan, Olaleye, Omonike Arike, Liang, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102341/ https://www.ncbi.nlm.nih.gov/pubmed/35566205 http://dx.doi.org/10.3390/molecules27092854

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