Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex

Curcumin is a natural acidic polyphenol extracted from turmeric with a wide range of biological and pharmacological effects. However, the application of curcumin for animal production and human life is limited by a low oral bioavailability. In this study, natural curcumin was prepared for the curcum...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Wanrong, Chen, Xizhao, Dai, Chongshan, Lin, Degui, Pang, Xuelin, Zhang, Di, Liu, Gang, Jin, Yipeng, Lin, Jiahao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102399/
https://www.ncbi.nlm.nih.gov/pubmed/35566349
http://dx.doi.org/10.3390/molecules27092998
_version_ 1784707319341252608
author Song, Wanrong
Chen, Xizhao
Dai, Chongshan
Lin, Degui
Pang, Xuelin
Zhang, Di
Liu, Gang
Jin, Yipeng
Lin, Jiahao
author_facet Song, Wanrong
Chen, Xizhao
Dai, Chongshan
Lin, Degui
Pang, Xuelin
Zhang, Di
Liu, Gang
Jin, Yipeng
Lin, Jiahao
author_sort Song, Wanrong
collection PubMed
description Curcumin is a natural acidic polyphenol extracted from turmeric with a wide range of biological and pharmacological effects. However, the application of curcumin for animal production and human life is limited by a low oral bioavailability. In this study, natural curcumin was prepared for the curcumin β-cyclodextrin inclusion complex (CUR-β-CD), curcumin solid dispersion (CUR-PEG-6000), and curcumin phospholipid complex (CUR-HSPC) using co-precipitation, melting, and solvent methods, respectively. Curcumin complex formations were monitored using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR) techniques via the shifts in the microscopic structure, molecular structure, and crystalline state. Subsequently, twenty-four female beagle dogs were randomly divided into four groups to receive unmodified curcumin and three other curcumin preparations. The validated UPLC–MS assay was successfully applied to pharmacokinetic and bioavailability studies of curcumin in beagle dog plasma, which were collected after dosing at 0 min (predose), 5 min, 15 min, 30 min, 40 min, 50 min, 1.5 h, 3 h, 4.5 h, 5.5 h, 6 h, 6.5 h, 9 h, and 24 h. The relative bioavailabilities of CUR-β-CD, CUR-PEG-6000, and CUR-HSPC were 231.94%, 272.37%, and 196.42%, respectively. This confirmed that CUR-β-CD, CUR-HSPC, and especially CUR-PEG-6000 could effectively improve the bioavailability of curcumin.
format Online
Article
Text
id pubmed-9102399
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91023992022-05-14 Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex Song, Wanrong Chen, Xizhao Dai, Chongshan Lin, Degui Pang, Xuelin Zhang, Di Liu, Gang Jin, Yipeng Lin, Jiahao Molecules Article Curcumin is a natural acidic polyphenol extracted from turmeric with a wide range of biological and pharmacological effects. However, the application of curcumin for animal production and human life is limited by a low oral bioavailability. In this study, natural curcumin was prepared for the curcumin β-cyclodextrin inclusion complex (CUR-β-CD), curcumin solid dispersion (CUR-PEG-6000), and curcumin phospholipid complex (CUR-HSPC) using co-precipitation, melting, and solvent methods, respectively. Curcumin complex formations were monitored using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR) techniques via the shifts in the microscopic structure, molecular structure, and crystalline state. Subsequently, twenty-four female beagle dogs were randomly divided into four groups to receive unmodified curcumin and three other curcumin preparations. The validated UPLC–MS assay was successfully applied to pharmacokinetic and bioavailability studies of curcumin in beagle dog plasma, which were collected after dosing at 0 min (predose), 5 min, 15 min, 30 min, 40 min, 50 min, 1.5 h, 3 h, 4.5 h, 5.5 h, 6 h, 6.5 h, 9 h, and 24 h. The relative bioavailabilities of CUR-β-CD, CUR-PEG-6000, and CUR-HSPC were 231.94%, 272.37%, and 196.42%, respectively. This confirmed that CUR-β-CD, CUR-HSPC, and especially CUR-PEG-6000 could effectively improve the bioavailability of curcumin. MDPI 2022-05-07 /pmc/articles/PMC9102399/ /pubmed/35566349 http://dx.doi.org/10.3390/molecules27092998 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Song, Wanrong
Chen, Xizhao
Dai, Chongshan
Lin, Degui
Pang, Xuelin
Zhang, Di
Liu, Gang
Jin, Yipeng
Lin, Jiahao
Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex
title Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex
title_full Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex
title_fullStr Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex
title_full_unstemmed Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex
title_short Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex
title_sort comparative study of preparation, evaluation, and pharmacokinetics in beagle dogs of curcumin β-cyclodextrin inclusion complex, curcumin solid dispersion, and curcumin phospholipid complex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102399/
https://www.ncbi.nlm.nih.gov/pubmed/35566349
http://dx.doi.org/10.3390/molecules27092998
work_keys_str_mv AT songwanrong comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex
AT chenxizhao comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex
AT daichongshan comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex
AT lindegui comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex
AT pangxuelin comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex
AT zhangdi comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex
AT liugang comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex
AT jinyipeng comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex
AT linjiahao comparativestudyofpreparationevaluationandpharmacokineticsinbeagledogsofcurcuminbcyclodextrininclusioncomplexcurcuminsoliddispersionandcurcuminphospholipidcomplex