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Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals

Insulin resistance (IR) is a major contributor to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity for the assessment of IR and NAFLD due to its ease of acquisition and calculation. Therefore, we conducted this systemat...

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Autores principales: Beran, Azizullah, Ayesh, Hazem, Mhanna, Mohammed, Wahood, Waseem, Ghazaleh, Sami, Abuhelwa, Ziad, Sayeh, Wasef, Aladamat, Nameer, Musallam, Rami, Matar, Reem, Malhas, Saif-Eddin, Assaly, Ragheb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102411/
https://www.ncbi.nlm.nih.gov/pubmed/35566790
http://dx.doi.org/10.3390/jcm11092666
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author Beran, Azizullah
Ayesh, Hazem
Mhanna, Mohammed
Wahood, Waseem
Ghazaleh, Sami
Abuhelwa, Ziad
Sayeh, Wasef
Aladamat, Nameer
Musallam, Rami
Matar, Reem
Malhas, Saif-Eddin
Assaly, Ragheb
author_facet Beran, Azizullah
Ayesh, Hazem
Mhanna, Mohammed
Wahood, Waseem
Ghazaleh, Sami
Abuhelwa, Ziad
Sayeh, Wasef
Aladamat, Nameer
Musallam, Rami
Matar, Reem
Malhas, Saif-Eddin
Assaly, Ragheb
author_sort Beran, Azizullah
collection PubMed
description Insulin resistance (IR) is a major contributor to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity for the assessment of IR and NAFLD due to its ease of acquisition and calculation. Therefore, we conducted this systematic review and meta-analysis to summarize the existing studies in the literature and provide a quantitative assessment of the significance of the TyG index in predicting the incidence of NAFLD. A comprehensive literature search in PubMed, EMBASE, and Web of Science databases from inception until 25 March 2022 was conducted. Published observational studies that evaluated the association between TyG index and NAFLD among the adult population and reported the hazard ratio (HR) or odds ratio (OR) for this association after multivariate analysis were included. The random-effects model was used as the primary statistical analysis model in the estimation of pooled ORs and HRs with the corresponding confidence intervals (CIs). A total of 17 observational studies, including 121,975 participants, were included. For studies analyzing the TyG index as a categorical variable, both pooled OR (6.00, CI 4.12–8.74) and HR (1.70, CI 1.28–2.27) were significant for the association between TyG index and incident NAFLD. For studies analyzing the TyG index as a continuous variable, pooled OR (2.25, CI 1.66–3.04) showed similar results. Consistent results were obtained in subgroup analyses according to the study design, sample size, ethnicity, and diabetic status. In conclusion, our meta-analysis demonstrates that a higher TyG index is associated with higher odds of NAFLD. TyG index may serve as an independent predictive tool to screen patients at high risk of NAFLD in clinical practice, especially in primary care settings. Patients with a high TyG index should be referred for a liver ultrasound and start intense lifestyle modifications. However, further large-scale prospective cohort studies are necessary to validate our findings.
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spelling pubmed-91024112022-05-14 Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals Beran, Azizullah Ayesh, Hazem Mhanna, Mohammed Wahood, Waseem Ghazaleh, Sami Abuhelwa, Ziad Sayeh, Wasef Aladamat, Nameer Musallam, Rami Matar, Reem Malhas, Saif-Eddin Assaly, Ragheb J Clin Med Article Insulin resistance (IR) is a major contributor to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity for the assessment of IR and NAFLD due to its ease of acquisition and calculation. Therefore, we conducted this systematic review and meta-analysis to summarize the existing studies in the literature and provide a quantitative assessment of the significance of the TyG index in predicting the incidence of NAFLD. A comprehensive literature search in PubMed, EMBASE, and Web of Science databases from inception until 25 March 2022 was conducted. Published observational studies that evaluated the association between TyG index and NAFLD among the adult population and reported the hazard ratio (HR) or odds ratio (OR) for this association after multivariate analysis were included. The random-effects model was used as the primary statistical analysis model in the estimation of pooled ORs and HRs with the corresponding confidence intervals (CIs). A total of 17 observational studies, including 121,975 participants, were included. For studies analyzing the TyG index as a categorical variable, both pooled OR (6.00, CI 4.12–8.74) and HR (1.70, CI 1.28–2.27) were significant for the association between TyG index and incident NAFLD. For studies analyzing the TyG index as a continuous variable, pooled OR (2.25, CI 1.66–3.04) showed similar results. Consistent results were obtained in subgroup analyses according to the study design, sample size, ethnicity, and diabetic status. In conclusion, our meta-analysis demonstrates that a higher TyG index is associated with higher odds of NAFLD. TyG index may serve as an independent predictive tool to screen patients at high risk of NAFLD in clinical practice, especially in primary care settings. Patients with a high TyG index should be referred for a liver ultrasound and start intense lifestyle modifications. However, further large-scale prospective cohort studies are necessary to validate our findings. MDPI 2022-05-09 /pmc/articles/PMC9102411/ /pubmed/35566790 http://dx.doi.org/10.3390/jcm11092666 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beran, Azizullah
Ayesh, Hazem
Mhanna, Mohammed
Wahood, Waseem
Ghazaleh, Sami
Abuhelwa, Ziad
Sayeh, Wasef
Aladamat, Nameer
Musallam, Rami
Matar, Reem
Malhas, Saif-Eddin
Assaly, Ragheb
Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals
title Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals
title_full Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals
title_fullStr Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals
title_full_unstemmed Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals
title_short Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals
title_sort triglyceride-glucose index for early prediction of nonalcoholic fatty liver disease: a meta-analysis of 121,975 individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102411/
https://www.ncbi.nlm.nih.gov/pubmed/35566790
http://dx.doi.org/10.3390/jcm11092666
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