Cargando…

The Effects of COVID-19 on Clinical Outcomes of Non-COVID-19 Patients Hospitalized for Upper Gastrointestinal Bleeding during the Pandemic

This study aims to investigate the effects of COVID-19 on clinical outcomes of non-COVID-19 patients hospitalized for upper gastrointestinal bleeding (UGIB) during the pandemic. A retrospective review is conducted. We recruited patients with UGIB admitted during the pandemic’s first wave (April 2020...

Descripción completa

Detalles Bibliográficos
Autores principales: Pausawasdi, Nonthalee, Manomaiwong, Ekawat, Kaosombatwattana, Uayporn, Karaketklang, Khemajira, Charatcharoenwitthaya, Phunchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102445/
https://www.ncbi.nlm.nih.gov/pubmed/35566587
http://dx.doi.org/10.3390/jcm11092461
_version_ 1784707330320891904
author Pausawasdi, Nonthalee
Manomaiwong, Ekawat
Kaosombatwattana, Uayporn
Karaketklang, Khemajira
Charatcharoenwitthaya, Phunchai
author_facet Pausawasdi, Nonthalee
Manomaiwong, Ekawat
Kaosombatwattana, Uayporn
Karaketklang, Khemajira
Charatcharoenwitthaya, Phunchai
author_sort Pausawasdi, Nonthalee
collection PubMed
description This study aims to investigate the effects of COVID-19 on clinical outcomes of non-COVID-19 patients hospitalized for upper gastrointestinal bleeding (UGIB) during the pandemic. A retrospective review is conducted. We recruited patients with UGIB admitted during the pandemic’s first wave (April 2020 to June 2020), and the year before the pandemic. The outcomes between the two groups were compared using propensity score matching (PSM). In total, 60 patients (pandemic group) and 460 patients (prepandemic group) are included. Patients admitted during the pandemic (mean age of 67 ± 14 years) had a mean Glasgow–Blatchford score of 10.8 ± 3.9. They were older (p = 0.045) with more underlying malignancies (p = 0.028), had less history of NSAID use (p = 0.010), had a lower platelet count (p = 0.007), and had lower serum albumin levels (p = 0.047) compared to those admitted before the pandemic. Esophagogastroduodenoscopy (EGD) was performed less frequently during the pandemic (43.3% vs. 95.4%, p < 0.001). Furthermore, the procedure was less likely to be performed within 24 h after admission (p < 0.001). After PSM, admissions during the pandemic were significantly associated with decreased chances of receiving an endoscopy (adjusted odds Ratio (OR), 0.02; 95% CI, 0.003–0.06, p < 0.001) and longer hospital stay (adjusted OR, 2.17; 95% CI, 1.13–3.20, p < 0.001). Additionally, there was a slight increase in 30-day mortality without statistical significance (adjusted OR, 1.92; 95% CI, 0.71–5.19, p = 0.199) and a marginally higher rebleeding rate (adjusted OR, 1.34; 95% CI, 0.44–4.03, p = 0.605). During the pandemic, the number of EGDs performed in non-COVID-19 patients with UGIB decreased with a subsequent prolonged hospitalization and potentially increased 30-day mortality and rebleeding rate.
format Online
Article
Text
id pubmed-9102445
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91024452022-05-14 The Effects of COVID-19 on Clinical Outcomes of Non-COVID-19 Patients Hospitalized for Upper Gastrointestinal Bleeding during the Pandemic Pausawasdi, Nonthalee Manomaiwong, Ekawat Kaosombatwattana, Uayporn Karaketklang, Khemajira Charatcharoenwitthaya, Phunchai J Clin Med Article This study aims to investigate the effects of COVID-19 on clinical outcomes of non-COVID-19 patients hospitalized for upper gastrointestinal bleeding (UGIB) during the pandemic. A retrospective review is conducted. We recruited patients with UGIB admitted during the pandemic’s first wave (April 2020 to June 2020), and the year before the pandemic. The outcomes between the two groups were compared using propensity score matching (PSM). In total, 60 patients (pandemic group) and 460 patients (prepandemic group) are included. Patients admitted during the pandemic (mean age of 67 ± 14 years) had a mean Glasgow–Blatchford score of 10.8 ± 3.9. They were older (p = 0.045) with more underlying malignancies (p = 0.028), had less history of NSAID use (p = 0.010), had a lower platelet count (p = 0.007), and had lower serum albumin levels (p = 0.047) compared to those admitted before the pandemic. Esophagogastroduodenoscopy (EGD) was performed less frequently during the pandemic (43.3% vs. 95.4%, p < 0.001). Furthermore, the procedure was less likely to be performed within 24 h after admission (p < 0.001). After PSM, admissions during the pandemic were significantly associated with decreased chances of receiving an endoscopy (adjusted odds Ratio (OR), 0.02; 95% CI, 0.003–0.06, p < 0.001) and longer hospital stay (adjusted OR, 2.17; 95% CI, 1.13–3.20, p < 0.001). Additionally, there was a slight increase in 30-day mortality without statistical significance (adjusted OR, 1.92; 95% CI, 0.71–5.19, p = 0.199) and a marginally higher rebleeding rate (adjusted OR, 1.34; 95% CI, 0.44–4.03, p = 0.605). During the pandemic, the number of EGDs performed in non-COVID-19 patients with UGIB decreased with a subsequent prolonged hospitalization and potentially increased 30-day mortality and rebleeding rate. MDPI 2022-04-27 /pmc/articles/PMC9102445/ /pubmed/35566587 http://dx.doi.org/10.3390/jcm11092461 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pausawasdi, Nonthalee
Manomaiwong, Ekawat
Kaosombatwattana, Uayporn
Karaketklang, Khemajira
Charatcharoenwitthaya, Phunchai
The Effects of COVID-19 on Clinical Outcomes of Non-COVID-19 Patients Hospitalized for Upper Gastrointestinal Bleeding during the Pandemic
title The Effects of COVID-19 on Clinical Outcomes of Non-COVID-19 Patients Hospitalized for Upper Gastrointestinal Bleeding during the Pandemic
title_full The Effects of COVID-19 on Clinical Outcomes of Non-COVID-19 Patients Hospitalized for Upper Gastrointestinal Bleeding during the Pandemic
title_fullStr The Effects of COVID-19 on Clinical Outcomes of Non-COVID-19 Patients Hospitalized for Upper Gastrointestinal Bleeding during the Pandemic
title_full_unstemmed The Effects of COVID-19 on Clinical Outcomes of Non-COVID-19 Patients Hospitalized for Upper Gastrointestinal Bleeding during the Pandemic
title_short The Effects of COVID-19 on Clinical Outcomes of Non-COVID-19 Patients Hospitalized for Upper Gastrointestinal Bleeding during the Pandemic
title_sort effects of covid-19 on clinical outcomes of non-covid-19 patients hospitalized for upper gastrointestinal bleeding during the pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102445/
https://www.ncbi.nlm.nih.gov/pubmed/35566587
http://dx.doi.org/10.3390/jcm11092461
work_keys_str_mv AT pausawasdinonthalee theeffectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT manomaiwongekawat theeffectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT kaosombatwattanauayporn theeffectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT karaketklangkhemajira theeffectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT charatcharoenwitthayaphunchai theeffectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT pausawasdinonthalee effectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT manomaiwongekawat effectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT kaosombatwattanauayporn effectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT karaketklangkhemajira effectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic
AT charatcharoenwitthayaphunchai effectsofcovid19onclinicaloutcomesofnoncovid19patientshospitalizedforuppergastrointestinalbleedingduringthepandemic