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Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior
Tumor heterogeneity poses one of the greatest challenges to a successful treatment of cancer. Tumor cell populations consist of different subpopulations that have distinct phenotypic and genotypic profiles. Such variability poses a challenge in successfully targeting all tumor subpopulations at the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102449/ https://www.ncbi.nlm.nih.gov/pubmed/35563709 http://dx.doi.org/10.3390/cells11091403 |
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author | Kumar, Vigneshwari Easwar Nambiar, Roshni De Souza, Cristabelle Nguyen, Audrey Chien, Jeremy Lam, Kit S. |
author_facet | Kumar, Vigneshwari Easwar Nambiar, Roshni De Souza, Cristabelle Nguyen, Audrey Chien, Jeremy Lam, Kit S. |
author_sort | Kumar, Vigneshwari Easwar |
collection | PubMed |
description | Tumor heterogeneity poses one of the greatest challenges to a successful treatment of cancer. Tumor cell populations consist of different subpopulations that have distinct phenotypic and genotypic profiles. Such variability poses a challenge in successfully targeting all tumor subpopulations at the same time. Relapse after treatment has been previously explained using the cancer stem cell model and the clonal evolution model. Cancer stem cells are an important subpopulation of tumor cells that regulate tumor plasticity and determine therapeutic resistance. Tumor plasticity is controlled by genetic and epigenetic changes of crucial genes involved in cancer cell survival, growth and metastasis. Targeting epigenetic modulators associated with cancer stem cell survival can unlock a promising therapeutic approach in completely eradicating cancer. Here, we review various factors governing epigenetic dysregulation of cancer stem cells ranging from the role of epigenetic mediators such as histone and DNA methyltransferases, histone deacetylases, histone methyltransferases to various signaling pathways associated with cancer stem cell regulation. We also discuss current treatment regimens targeting these factors and other promising inhibitors in clinical trials. |
format | Online Article Text |
id | pubmed-9102449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91024492022-05-14 Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior Kumar, Vigneshwari Easwar Nambiar, Roshni De Souza, Cristabelle Nguyen, Audrey Chien, Jeremy Lam, Kit S. Cells Review Tumor heterogeneity poses one of the greatest challenges to a successful treatment of cancer. Tumor cell populations consist of different subpopulations that have distinct phenotypic and genotypic profiles. Such variability poses a challenge in successfully targeting all tumor subpopulations at the same time. Relapse after treatment has been previously explained using the cancer stem cell model and the clonal evolution model. Cancer stem cells are an important subpopulation of tumor cells that regulate tumor plasticity and determine therapeutic resistance. Tumor plasticity is controlled by genetic and epigenetic changes of crucial genes involved in cancer cell survival, growth and metastasis. Targeting epigenetic modulators associated with cancer stem cell survival can unlock a promising therapeutic approach in completely eradicating cancer. Here, we review various factors governing epigenetic dysregulation of cancer stem cells ranging from the role of epigenetic mediators such as histone and DNA methyltransferases, histone deacetylases, histone methyltransferases to various signaling pathways associated with cancer stem cell regulation. We also discuss current treatment regimens targeting these factors and other promising inhibitors in clinical trials. MDPI 2022-04-21 /pmc/articles/PMC9102449/ /pubmed/35563709 http://dx.doi.org/10.3390/cells11091403 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kumar, Vigneshwari Easwar Nambiar, Roshni De Souza, Cristabelle Nguyen, Audrey Chien, Jeremy Lam, Kit S. Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior |
title | Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior |
title_full | Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior |
title_fullStr | Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior |
title_full_unstemmed | Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior |
title_short | Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior |
title_sort | targeting epigenetic modifiers of tumor plasticity and cancer stem cell behavior |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102449/ https://www.ncbi.nlm.nih.gov/pubmed/35563709 http://dx.doi.org/10.3390/cells11091403 |
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