Cargando…
Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study
SIMPLE SUMMARY: Ovarian cancer was the third most common gynecological cancer globally in 2020. Ovarian carcinoma is the most common type of ovarian cancer, comprising over 90% of all ovarian cancer cases. The risk of ovarian cancer increases in females with age, along with having a family history,...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102475/ https://www.ncbi.nlm.nih.gov/pubmed/35565359 http://dx.doi.org/10.3390/cancers14092230 |
_version_ | 1784707337397731328 |
---|---|
author | Huang, Junjie Chan, Wing Chung Ngai, Chun Ho Lok, Veeleah Zhang, Lin Lucero-Prisno, Don Eliseo Xu, Wanghong Zheng, Zhi-Jie Elcarte, Edmar Withers, Mellissa Wong, Martin C. S. |
author_facet | Huang, Junjie Chan, Wing Chung Ngai, Chun Ho Lok, Veeleah Zhang, Lin Lucero-Prisno, Don Eliseo Xu, Wanghong Zheng, Zhi-Jie Elcarte, Edmar Withers, Mellissa Wong, Martin C. S. |
author_sort | Huang, Junjie |
collection | PubMed |
description | SIMPLE SUMMARY: Ovarian cancer was the third most common gynecological cancer globally in 2020. Ovarian carcinoma is the most common type of ovarian cancer, comprising over 90% of all ovarian cancer cases. The risk of ovarian cancer increases in females with age, along with having a family history, having a family cancer syndrome, and breast cancer susceptibility gene (BRCA) mutations. Investigation of the latest disease burden, risk factors, and temporal trends of ovarian cancer is important for the reduction of its associated mortality globally. The global incidence and mortality rates of ovarian cancer for 185 countries in 2020 were retrieved from the Global Cancer Observatory (GLOBOCAN) database established by the International Agency for Research on Cancer (IARC, WHO, Lyon, France). The incidence of ovarian cancer has been increasing substantially among younger females, probably caused by the increasing prevalence of obesity, metabolic syndrome, estrogen exposure and nulliparity. ABSTRACT: This study aimed to investigate the most updated worldwide incidence and mortality, risk factors, and epidemiologic trend of ovarian cancer in different countries, regions, and age groups. The Global Cancer Observatory database was used for incidence and mortality rates of ovarian cancer in 2020. Data from Cancer Incidence in Five Continents and the WHO mortality database was accessed for trend analysis. Age-standardized rates (ASRs, per 100,000 persons) were calculated for incidence and mortality. The 10-year annual average percent change (AAPC) was estimated by Joinpoint regression analysis. There was an overall decreasing trend of ovarian cancer, yet its burden has been increasing in lower-income countries and among younger females in some countries. Intensive lifestyle modifications are warranted, especially for the populations at high risk for ovarian cancer, including smoking cessation, alcohol use reduction, physical activity, weight control, and treatment of metabolic diseases. |
format | Online Article Text |
id | pubmed-9102475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91024752022-05-14 Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study Huang, Junjie Chan, Wing Chung Ngai, Chun Ho Lok, Veeleah Zhang, Lin Lucero-Prisno, Don Eliseo Xu, Wanghong Zheng, Zhi-Jie Elcarte, Edmar Withers, Mellissa Wong, Martin C. S. Cancers (Basel) Article SIMPLE SUMMARY: Ovarian cancer was the third most common gynecological cancer globally in 2020. Ovarian carcinoma is the most common type of ovarian cancer, comprising over 90% of all ovarian cancer cases. The risk of ovarian cancer increases in females with age, along with having a family history, having a family cancer syndrome, and breast cancer susceptibility gene (BRCA) mutations. Investigation of the latest disease burden, risk factors, and temporal trends of ovarian cancer is important for the reduction of its associated mortality globally. The global incidence and mortality rates of ovarian cancer for 185 countries in 2020 were retrieved from the Global Cancer Observatory (GLOBOCAN) database established by the International Agency for Research on Cancer (IARC, WHO, Lyon, France). The incidence of ovarian cancer has been increasing substantially among younger females, probably caused by the increasing prevalence of obesity, metabolic syndrome, estrogen exposure and nulliparity. ABSTRACT: This study aimed to investigate the most updated worldwide incidence and mortality, risk factors, and epidemiologic trend of ovarian cancer in different countries, regions, and age groups. The Global Cancer Observatory database was used for incidence and mortality rates of ovarian cancer in 2020. Data from Cancer Incidence in Five Continents and the WHO mortality database was accessed for trend analysis. Age-standardized rates (ASRs, per 100,000 persons) were calculated for incidence and mortality. The 10-year annual average percent change (AAPC) was estimated by Joinpoint regression analysis. There was an overall decreasing trend of ovarian cancer, yet its burden has been increasing in lower-income countries and among younger females in some countries. Intensive lifestyle modifications are warranted, especially for the populations at high risk for ovarian cancer, including smoking cessation, alcohol use reduction, physical activity, weight control, and treatment of metabolic diseases. MDPI 2022-04-29 /pmc/articles/PMC9102475/ /pubmed/35565359 http://dx.doi.org/10.3390/cancers14092230 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Junjie Chan, Wing Chung Ngai, Chun Ho Lok, Veeleah Zhang, Lin Lucero-Prisno, Don Eliseo Xu, Wanghong Zheng, Zhi-Jie Elcarte, Edmar Withers, Mellissa Wong, Martin C. S. Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study |
title | Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study |
title_full | Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study |
title_fullStr | Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study |
title_full_unstemmed | Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study |
title_short | Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study |
title_sort | worldwide burden, risk factors, and temporal trends of ovarian cancer: a global study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102475/ https://www.ncbi.nlm.nih.gov/pubmed/35565359 http://dx.doi.org/10.3390/cancers14092230 |
work_keys_str_mv | AT huangjunjie worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT chanwingchung worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT ngaichunho worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT lokveeleah worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT zhanglin worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT luceroprisnodoneliseo worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT xuwanghong worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT zhengzhijie worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT elcarteedmar worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT withersmellissa worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT wongmartincs worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy AT worldwideburdenriskfactorsandtemporaltrendsofovariancanceraglobalstudy |