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RNA‐binding proteins in diabetic microangiopathy
BACKGROUND: As the most common complication of diabetes, the diabetic microangiopathy characterizes diabetic retinopathy (DR) and nephropathy (DN). Diabetic microangiopathy has always been a serious clinical problem. A wide variety of nucleic acid interacting factors called the RNA binding proteins...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102490/ https://www.ncbi.nlm.nih.gov/pubmed/35385161 http://dx.doi.org/10.1002/jcla.24407 |
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author | Tu, Chao Wang, Liangzhi Wei, Lan |
author_facet | Tu, Chao Wang, Liangzhi Wei, Lan |
author_sort | Tu, Chao |
collection | PubMed |
description | BACKGROUND: As the most common complication of diabetes, the diabetic microangiopathy characterizes diabetic retinopathy (DR) and nephropathy (DN). Diabetic microangiopathy has always been a serious clinical problem. A wide variety of nucleic acid interacting factors called the RNA binding proteins (RBPS) take part in several crucial cellular processes. METHODS: Over the past decade, studies have shown that RBPs have crucial part in both malignant tumors and diabetes, especially in diabetic microangiopathy. This review examined the research history of RBPS in DR and DN. RESULTS: We reviewed the literature and found that RBPS is potentially useful as therapeutic targets, diagnostic markers, or predict disease progression. CONCLUSION: HuR acts as a vital therapeutic targeting protein in diabetic microangiopathy. IGF2BP2, P311, TTP, YBX1, and MBNL1 have a potential role in the treatment of DN. |
format | Online Article Text |
id | pubmed-9102490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91024902022-05-18 RNA‐binding proteins in diabetic microangiopathy Tu, Chao Wang, Liangzhi Wei, Lan J Clin Lab Anal Review Article BACKGROUND: As the most common complication of diabetes, the diabetic microangiopathy characterizes diabetic retinopathy (DR) and nephropathy (DN). Diabetic microangiopathy has always been a serious clinical problem. A wide variety of nucleic acid interacting factors called the RNA binding proteins (RBPS) take part in several crucial cellular processes. METHODS: Over the past decade, studies have shown that RBPs have crucial part in both malignant tumors and diabetes, especially in diabetic microangiopathy. This review examined the research history of RBPS in DR and DN. RESULTS: We reviewed the literature and found that RBPS is potentially useful as therapeutic targets, diagnostic markers, or predict disease progression. CONCLUSION: HuR acts as a vital therapeutic targeting protein in diabetic microangiopathy. IGF2BP2, P311, TTP, YBX1, and MBNL1 have a potential role in the treatment of DN. John Wiley and Sons Inc. 2022-04-06 /pmc/articles/PMC9102490/ /pubmed/35385161 http://dx.doi.org/10.1002/jcla.24407 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Article Tu, Chao Wang, Liangzhi Wei, Lan RNA‐binding proteins in diabetic microangiopathy |
title | RNA‐binding proteins in diabetic microangiopathy |
title_full | RNA‐binding proteins in diabetic microangiopathy |
title_fullStr | RNA‐binding proteins in diabetic microangiopathy |
title_full_unstemmed | RNA‐binding proteins in diabetic microangiopathy |
title_short | RNA‐binding proteins in diabetic microangiopathy |
title_sort | rna‐binding proteins in diabetic microangiopathy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102490/ https://www.ncbi.nlm.nih.gov/pubmed/35385161 http://dx.doi.org/10.1002/jcla.24407 |
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