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The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety
We investigated the presence of a molecular pathway from hepatic 11-βHSD-1 to brain MAO-A in the dynamics of plasma corticosterone involvement in anxiety development. During 14 days following repeated exposure of rats to predator scent stress for 10 days, the following variables were measured: hepat...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102549/ https://www.ncbi.nlm.nih.gov/pubmed/35563271 http://dx.doi.org/10.3390/ijms23094881 |
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author | Tseilikman, Vadim Lapshin, Maxim Klebanov, Igor Chrousos, George Vasilieva, Maria Pashkov, Anton Fedotova, Julia Tseilikman, David Shatilov, Vladislav Manukhina, Eugenia Tseilikman, Olga Sarapultsev, Alexey Downey, H. Fred |
author_facet | Tseilikman, Vadim Lapshin, Maxim Klebanov, Igor Chrousos, George Vasilieva, Maria Pashkov, Anton Fedotova, Julia Tseilikman, David Shatilov, Vladislav Manukhina, Eugenia Tseilikman, Olga Sarapultsev, Alexey Downey, H. Fred |
author_sort | Tseilikman, Vadim |
collection | PubMed |
description | We investigated the presence of a molecular pathway from hepatic 11-βHSD-1 to brain MAO-A in the dynamics of plasma corticosterone involvement in anxiety development. During 14 days following repeated exposure of rats to predator scent stress for 10 days, the following variables were measured: hepatic 11-βHSD-1 and brain MAO-A activities, brain norepinephrine, plasma corticosterone concentrations, and anxiety, as reflected by performance on an elevated plus maze. Anxiety briefly decreased and then increased after stress exposure. This behavioral response correlated inversely with plasma corticosterone and with brain MAO-A activity. A mathematical model described the dynamics of the biochemical variables and predicted the factor(s) responsible for the development and dynamics of anxiety. In the model, hepatic 11-βHSD-1 was considered a key factor in defining the dynamics of plasma corticosterone. In turn, plasma corticosterone and oxidation of brain ketodienes and conjugated trienes determined the dynamics of brain MAO-A activity, and MAO-A activity determined the dynamics of brain norepinephrine. Finally, plasma corticosterone was modeled as the determinant of anxiety. Solution of the model equations demonstrated that plasma corticosterone is mainly determined by the activity of hepatic 11-βHSD-1 and, most importantly, that corticosterone plays a critical role in the dynamics of anxiety following repeated stress. |
format | Online Article Text |
id | pubmed-9102549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91025492022-05-14 The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety Tseilikman, Vadim Lapshin, Maxim Klebanov, Igor Chrousos, George Vasilieva, Maria Pashkov, Anton Fedotova, Julia Tseilikman, David Shatilov, Vladislav Manukhina, Eugenia Tseilikman, Olga Sarapultsev, Alexey Downey, H. Fred Int J Mol Sci Article We investigated the presence of a molecular pathway from hepatic 11-βHSD-1 to brain MAO-A in the dynamics of plasma corticosterone involvement in anxiety development. During 14 days following repeated exposure of rats to predator scent stress for 10 days, the following variables were measured: hepatic 11-βHSD-1 and brain MAO-A activities, brain norepinephrine, plasma corticosterone concentrations, and anxiety, as reflected by performance on an elevated plus maze. Anxiety briefly decreased and then increased after stress exposure. This behavioral response correlated inversely with plasma corticosterone and with brain MAO-A activity. A mathematical model described the dynamics of the biochemical variables and predicted the factor(s) responsible for the development and dynamics of anxiety. In the model, hepatic 11-βHSD-1 was considered a key factor in defining the dynamics of plasma corticosterone. In turn, plasma corticosterone and oxidation of brain ketodienes and conjugated trienes determined the dynamics of brain MAO-A activity, and MAO-A activity determined the dynamics of brain norepinephrine. Finally, plasma corticosterone was modeled as the determinant of anxiety. Solution of the model equations demonstrated that plasma corticosterone is mainly determined by the activity of hepatic 11-βHSD-1 and, most importantly, that corticosterone plays a critical role in the dynamics of anxiety following repeated stress. MDPI 2022-04-28 /pmc/articles/PMC9102549/ /pubmed/35563271 http://dx.doi.org/10.3390/ijms23094881 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tseilikman, Vadim Lapshin, Maxim Klebanov, Igor Chrousos, George Vasilieva, Maria Pashkov, Anton Fedotova, Julia Tseilikman, David Shatilov, Vladislav Manukhina, Eugenia Tseilikman, Olga Sarapultsev, Alexey Downey, H. Fred The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety |
title | The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety |
title_full | The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety |
title_fullStr | The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety |
title_full_unstemmed | The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety |
title_short | The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety |
title_sort | link between activities of hepatic 11beta-hydroxysteroid dehydrogenase-1 and monoamine oxidase-a in the brain following repeated predator stress: focus on heightened anxiety |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102549/ https://www.ncbi.nlm.nih.gov/pubmed/35563271 http://dx.doi.org/10.3390/ijms23094881 |
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