Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function. Chronic inflammation has been demonstrated to be the pathological basis of fibr...

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Autores principales: Nie, Yun-Juan, Wu, Shuo-Hua, Xuan, Ying-Hua, Yan, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102601/
https://www.ncbi.nlm.nih.gov/pubmed/35550651
http://dx.doi.org/10.1186/s40779-022-00382-3
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author Nie, Yun-Juan
Wu, Shuo-Hua
Xuan, Ying-Hua
Yan, Gen
author_facet Nie, Yun-Juan
Wu, Shuo-Hua
Xuan, Ying-Hua
Yan, Gen
author_sort Nie, Yun-Juan
collection PubMed
description Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function. Chronic inflammation has been demonstrated to be the pathological basis of fibrosis. Emerging studies have revealed that most interleukin-17 (IL-17) isoforms are essential for the mediation of acute and chronic inflammation via innate and adaptive immunity. Overexpression or aberrant expression of IL-17 cytokines contributes to various pathological outcomes, including the initiation and exacerbation of IPF. Here, we aim to provide an overview of IL-17 family members in the pathogenesis of IPF.
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spelling pubmed-91026012022-05-14 Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis Nie, Yun-Juan Wu, Shuo-Hua Xuan, Ying-Hua Yan, Gen Mil Med Res Review Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function. Chronic inflammation has been demonstrated to be the pathological basis of fibrosis. Emerging studies have revealed that most interleukin-17 (IL-17) isoforms are essential for the mediation of acute and chronic inflammation via innate and adaptive immunity. Overexpression or aberrant expression of IL-17 cytokines contributes to various pathological outcomes, including the initiation and exacerbation of IPF. Here, we aim to provide an overview of IL-17 family members in the pathogenesis of IPF. BioMed Central 2022-05-12 /pmc/articles/PMC9102601/ /pubmed/35550651 http://dx.doi.org/10.1186/s40779-022-00382-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Nie, Yun-Juan
Wu, Shuo-Hua
Xuan, Ying-Hua
Yan, Gen
Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
title Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
title_full Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
title_fullStr Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
title_full_unstemmed Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
title_short Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
title_sort role of il-17 family cytokines in the progression of ipf from inflammation to fibrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102601/
https://www.ncbi.nlm.nih.gov/pubmed/35550651
http://dx.doi.org/10.1186/s40779-022-00382-3
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