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Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study

BACKGROUND AND AIMS: Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial o...

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Autores principales: Cheng, Yu, Liu, Shuai, Chen, Duo, Yang, Yiman, Liang, Qiongyue, Huo, Ya, Zhou, Ziyi, Zhang, Nan, Wang, Zhuo, Liu, Lishun, Song, Yun, Liu, Xiangyi, Duan, Yong, Liang, Xiuwen, Hou, Bingjie, Wang, Binyan, Tang, Genfu, Qin, Xianhui, Yan, Fangrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102656/
https://www.ncbi.nlm.nih.gov/pubmed/35562805
http://dx.doi.org/10.1186/s12937-022-00786-w
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author Cheng, Yu
Liu, Shuai
Chen, Duo
Yang, Yiman
Liang, Qiongyue
Huo, Ya
Zhou, Ziyi
Zhang, Nan
Wang, Zhuo
Liu, Lishun
Song, Yun
Liu, Xiangyi
Duan, Yong
Liang, Xiuwen
Hou, Bingjie
Wang, Binyan
Tang, Genfu
Qin, Xianhui
Yan, Fangrong
author_facet Cheng, Yu
Liu, Shuai
Chen, Duo
Yang, Yiman
Liang, Qiongyue
Huo, Ya
Zhou, Ziyi
Zhang, Nan
Wang, Zhuo
Liu, Lishun
Song, Yun
Liu, Xiangyi
Duan, Yong
Liang, Xiuwen
Hou, Bingjie
Wang, Binyan
Tang, Genfu
Qin, Xianhui
Yan, Fangrong
author_sort Cheng, Yu
collection PubMed
description BACKGROUND AND AIMS: Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. This study aimed to reveal the association between these two biochemical indices. METHODS: Study population was drawn from the baseline data of the China Stroke Primary Prevention Trial (CSPPT), including 2328 hypertensive participants. 5-methyltetrahydrofolate and homocysteine were determined by stable-isotope dilution liquid chromatography-tandem mass spectrometry and automatic clinical analyzers, respectively. MTHFR C677T polymorphisms were detected using TaqMan assay. Multiple linear regression was performed to evaluate the association between serum 5-methyltetrahydrofolate and homocysteine. RESULTS: There was a significant inverse association between 5-methyltetrahydrofolate and homocysteine when 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T (per 1-ng/mL increment; All: β = − 0.50, P <  0.001; CC: β = − 0.14, P = 0.087; CT: β = − 0.20, P = 0.011; TT: β = − 1.19, P <  0.001). Moreover, the decline in trend in genotype TT participants was stronger than in genotype CC participants (P for difference <  0.001) and genotype CT participants (P for difference <  0.001), while there was no significant difference between genotype CC and genotype CT participants (P for difference = 0.757). CONCLUSIONS: Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12937-022-00786-w.
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spelling pubmed-91026562022-05-14 Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study Cheng, Yu Liu, Shuai Chen, Duo Yang, Yiman Liang, Qiongyue Huo, Ya Zhou, Ziyi Zhang, Nan Wang, Zhuo Liu, Lishun Song, Yun Liu, Xiangyi Duan, Yong Liang, Xiuwen Hou, Bingjie Wang, Binyan Tang, Genfu Qin, Xianhui Yan, Fangrong Nutr J Research BACKGROUND AND AIMS: Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. This study aimed to reveal the association between these two biochemical indices. METHODS: Study population was drawn from the baseline data of the China Stroke Primary Prevention Trial (CSPPT), including 2328 hypertensive participants. 5-methyltetrahydrofolate and homocysteine were determined by stable-isotope dilution liquid chromatography-tandem mass spectrometry and automatic clinical analyzers, respectively. MTHFR C677T polymorphisms were detected using TaqMan assay. Multiple linear regression was performed to evaluate the association between serum 5-methyltetrahydrofolate and homocysteine. RESULTS: There was a significant inverse association between 5-methyltetrahydrofolate and homocysteine when 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T (per 1-ng/mL increment; All: β = − 0.50, P <  0.001; CC: β = − 0.14, P = 0.087; CT: β = − 0.20, P = 0.011; TT: β = − 1.19, P <  0.001). Moreover, the decline in trend in genotype TT participants was stronger than in genotype CC participants (P for difference <  0.001) and genotype CT participants (P for difference <  0.001), while there was no significant difference between genotype CC and genotype CT participants (P for difference = 0.757). CONCLUSIONS: Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12937-022-00786-w. BioMed Central 2022-05-13 /pmc/articles/PMC9102656/ /pubmed/35562805 http://dx.doi.org/10.1186/s12937-022-00786-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Cheng, Yu
Liu, Shuai
Chen, Duo
Yang, Yiman
Liang, Qiongyue
Huo, Ya
Zhou, Ziyi
Zhang, Nan
Wang, Zhuo
Liu, Lishun
Song, Yun
Liu, Xiangyi
Duan, Yong
Liang, Xiuwen
Hou, Bingjie
Wang, Binyan
Tang, Genfu
Qin, Xianhui
Yan, Fangrong
Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study
title Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study
title_full Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study
title_fullStr Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study
title_full_unstemmed Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study
title_short Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study
title_sort association between serum 5-methyltetrahydrofolate and homocysteine in chinese hypertensive participants with different mthfr c677t polymorphisms: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102656/
https://www.ncbi.nlm.nih.gov/pubmed/35562805
http://dx.doi.org/10.1186/s12937-022-00786-w
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