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Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients

BACKGROUND: Cancer causes a serious health burden on patients worldwide. Chronic low‐level inflammation plays a key role in tumorigenesis and prognosis. However, the role of the red blood cell distribution width (RDW)‐to‐albumin (RA) ratio in cancer mortality remains unclear. METHODS: In this retros...

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Autores principales: Lu, Chengdong, Long, Jianyun, Liu, Haiyuan, Xie, Xupin, Xu, Dong, Fang, Xin, Zhu, Yuandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102686/
https://www.ncbi.nlm.nih.gov/pubmed/35396747
http://dx.doi.org/10.1002/jcla.24423
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author Lu, Chengdong
Long, Jianyun
Liu, Haiyuan
Xie, Xupin
Xu, Dong
Fang, Xin
Zhu, Yuandong
author_facet Lu, Chengdong
Long, Jianyun
Liu, Haiyuan
Xie, Xupin
Xu, Dong
Fang, Xin
Zhu, Yuandong
author_sort Lu, Chengdong
collection PubMed
description BACKGROUND: Cancer causes a serious health burden on patients worldwide. Chronic low‐level inflammation plays a key role in tumorigenesis and prognosis. However, the role of the red blood cell distribution width (RDW)‐to‐albumin (RA) ratio in cancer mortality remains unclear. METHODS: In this retrospective cohort study, we collected clinical information from cancer patients from the Medical Information Mart for Intensive Care III (MIMIC‐III) version 1.4 database and then calculated RA by dividing RDW by albumin concentration. The primary outcome was 30 days mortality, while secondary outcomes were 90 days and 1 year mortality. Next, we adopted Cox regression models to calculate hazard ratios (HR) together with 95% confidence intervals (CI) for all‐cause mortalities associated with the RA ratio. RESULTS: For 30 days mortality, the HR (95% CI) for the high RA ratio (≥5.51) was 2.17 [95CI% (1.87–2.51); p = <0.0001], compared with the low RA ratio (<5.51). In Model 2, we adjusted sex and age and obtained HR (95% CI) of 2.17 [95CI% (1.87–2.52); p = <0.0001] for the high RA ratio (≥5.51) group, compared to that in the low RA ratio (<5.51). In Model 3, adjusting for age, sex, anion gap, hematocrit, white blood cell count, congestive heart failure, SOFA, liver disease, and renal failure resulted in HR (95% CI) of 1.74 [95CI% (1.48–2.04); p = <0.0001] for the high RA ratio (≥5.51) relative to the low RA ratio (<5.51). We also analyzed common diseases in cancer patients but found no significant association. CONCLUSION: To the best of our knowledge, this is the first study demonstrating that increased RA ratio is independently associated with increased all‐cause mortality in cancer patients.
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spelling pubmed-91026862022-05-18 Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients Lu, Chengdong Long, Jianyun Liu, Haiyuan Xie, Xupin Xu, Dong Fang, Xin Zhu, Yuandong J Clin Lab Anal Research Articles BACKGROUND: Cancer causes a serious health burden on patients worldwide. Chronic low‐level inflammation plays a key role in tumorigenesis and prognosis. However, the role of the red blood cell distribution width (RDW)‐to‐albumin (RA) ratio in cancer mortality remains unclear. METHODS: In this retrospective cohort study, we collected clinical information from cancer patients from the Medical Information Mart for Intensive Care III (MIMIC‐III) version 1.4 database and then calculated RA by dividing RDW by albumin concentration. The primary outcome was 30 days mortality, while secondary outcomes were 90 days and 1 year mortality. Next, we adopted Cox regression models to calculate hazard ratios (HR) together with 95% confidence intervals (CI) for all‐cause mortalities associated with the RA ratio. RESULTS: For 30 days mortality, the HR (95% CI) for the high RA ratio (≥5.51) was 2.17 [95CI% (1.87–2.51); p = <0.0001], compared with the low RA ratio (<5.51). In Model 2, we adjusted sex and age and obtained HR (95% CI) of 2.17 [95CI% (1.87–2.52); p = <0.0001] for the high RA ratio (≥5.51) group, compared to that in the low RA ratio (<5.51). In Model 3, adjusting for age, sex, anion gap, hematocrit, white blood cell count, congestive heart failure, SOFA, liver disease, and renal failure resulted in HR (95% CI) of 1.74 [95CI% (1.48–2.04); p = <0.0001] for the high RA ratio (≥5.51) relative to the low RA ratio (<5.51). We also analyzed common diseases in cancer patients but found no significant association. CONCLUSION: To the best of our knowledge, this is the first study demonstrating that increased RA ratio is independently associated with increased all‐cause mortality in cancer patients. John Wiley and Sons Inc. 2022-04-08 /pmc/articles/PMC9102686/ /pubmed/35396747 http://dx.doi.org/10.1002/jcla.24423 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Lu, Chengdong
Long, Jianyun
Liu, Haiyuan
Xie, Xupin
Xu, Dong
Fang, Xin
Zhu, Yuandong
Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients
title Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients
title_full Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients
title_fullStr Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients
title_full_unstemmed Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients
title_short Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients
title_sort red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102686/
https://www.ncbi.nlm.nih.gov/pubmed/35396747
http://dx.doi.org/10.1002/jcla.24423
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