Cargando…

Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration

Cancer metastasis accounts for most of the mortality associated with solid tumors. However, antimetastatic drugs are not available on the market. One of the important biological events leading to metastasis is the epithelial to mesenchymal transition (EMT) induced by cytokines, namely transforming g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toma, Tsugumasa, Tateishi, Hiroshi, Kawakami, Kensaku, Ali, Taha F. S., Kamo, Masahiro, Monde, Kazuaki, Nakashima, Yuta, Fujita, Mikako, Otsuka, Masami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102712/ https://www.ncbi.nlm.nih.gov/pubmed/35563439 http://dx.doi.org/10.3390/ijms23095047

Ejemplares similares

New Insights into the Structural Requirements of Isatin-Derived Pro-Apoptotic Agents against Acute Myeloid Leukemia
por: Hamdy, Ahmed K., et al.
Publicado: (2022)

A clue to unprecedented strategy to HIV eradication: “Lock-in and apoptosis”
por: Tateishi, Hiroshi, et al.
Publicado: (2017)

A New Series of Indeno[1,2-c]pyrazoles as EGFR TK Inhibitors for NSCLC Therapy
por: Özdemir, Ahmet, et al.
Publicado: (2022)

Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity
por: Ali, Taha F. S., et al.
Publicado: (2022)

SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein
por: Fujita, Mikako, et al.
Publicado: (2012)

Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis
por: Sever, Belgin, et al.
Publicado: (2022)

Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein
por: Ciftci, Halilibrahim, et al.
Publicado: (2021)

Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement
por: Radwan, Mohamed O., et al.
Publicado: (2019)

In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Introduction of H2C2‐type zinc‐binding residues into HIV‐2 Vpr increases its expression level
por: Koga, Ryoko, et al.
Publicado: (2017)

Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors
por: Sever, Belgin, et al.
Publicado: (2020)

Gypsogenin Battling for a Front Position in the Pentacyclic Triterpenes Game of Thrones on Anti-Cancer Therapy: A Critical Review—Dedicated to the Memory of Professor Hanaa M. Rady
por: Radwan, Mohamed O., et al.
Publicado: (2023)

In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Harnessing Oleanolic Acid and Its Derivatives as Modulators of Metabolic Nuclear Receptors
por: Radwan, Mohamed O., et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity
por: I. Ciftci, Halil, et al.
Publicado: (2019)

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1
por: Frey, Patrick, et al.
Publicado: (2020)

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents
por: Karabacak, Muhammed, et al.
Publicado: (2015)

Dextran sulfate inhibition on human gastric cancer cells invasion, migration and epithelial-mesenchymal transformation
por: Xu, Yuanyi, et al.
Publicado: (2018)

Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2017)

Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress
por: Shah, Parag P., et al.
Publicado: (2017)

Atorvastatin regulates the migration and invasion of prostate cancer through the epithelial-mesenchymal transformation and matrix metalloproteinase pathways
por: Zhu, Zhanmeng, et al.
Publicado: (2022)

Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature
por: I Ciftci, Halil, et al.
Publicado: (2019)

T-Plastin Expression Downstream to the Calcineurin/NFAT Pathway Is Involved in Keratinocyte Migration
por: Brun, Cécilia, et al.
Publicado: (2014)

Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling
por: Norris, Megan L, et al.
Publicado: (2017)

EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy
por: Ciftci, Halil I., et al.
Publicado: (2021)

Inhibition of autophagy by 3-methyladenine promotes migration and invasion of colon cancer cells through epithelial mesenchymal transformation
por: Zhang, Xiaoyang, et al.
Publicado: (2022)

Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling
por: Ray, Poulomi, et al.
Publicado: (2015)

FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42
por: Block, Jennifer, et al.
Publicado: (2012)

Structural Characterization of TRAF6 N-Terminal for Therapeutic Uses and Computational Studies on New Derivatives
por: Guven, Omur, et al.
Publicado: (2023)

FGF23 and Fetuin-A Interaction and Mesenchymal Osteogenic Transformation
por: Mattinzoli, Deborah, et al.
Publicado: (2019)

Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease
por: Nahar, Saifun, et al.
Publicado: (2018)

Transforming growth factor-β1 suppresses bone morphogenetic protein-2-induced mesenchymal-epithelial transition in HSC-4 human oral squamous cell carcinoma cells via Smad1/5/9 pathway suppression
por: Chiba, Takahiro, et al.
Publicado: (2017)

Plectin Downregulation Inhibits Migration and Suppresses Epithelial Mesenchymal Transformation of Hepatocellular Carcinoma Cells via ERK1/2 Signaling
por: Xu, Rushuang, et al.
Publicado: (2022)

Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion
por: Harada, Akikazu, et al.
Publicado: (2021)

PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation
por: Shimizu, Takashi, et al.
Publicado: (2020)

Identification of Proteins Differentially Expressed by Adipose-derived Mesenchymal Stem Cells Isolated from Immunodeficient Mice
por: Nakashima, Yoshiki, et al.
Publicado: (2019)

Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
por: Shida, Wataru, et al.
Publicado: (2019)

Designing clinical-grade integrated strategies for the downstream processing of human mesenchymal stem cells
por: Cunha, Bárbara, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_811cussv2g5dov6059k83m5ava