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Polysialylation in a DISC1 Mutant Mouse

Schizophrenia is a serious psychiatric disorder that affects the social life of patients. Psychiatric disorders are caused by a complex combination of genetic (G) and environmental (E) factors. Polysialylation represents a unique posttranslational modification of a protein, and such changes in neura...

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Autores principales: Takahashi, Yuka, Abe, Chikara, Hane, Masaya, Wu, Di, Kitajima, Ken, Sato, Chihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102787/
https://www.ncbi.nlm.nih.gov/pubmed/35563598
http://dx.doi.org/10.3390/ijms23095207
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author Takahashi, Yuka
Abe, Chikara
Hane, Masaya
Wu, Di
Kitajima, Ken
Sato, Chihiro
author_facet Takahashi, Yuka
Abe, Chikara
Hane, Masaya
Wu, Di
Kitajima, Ken
Sato, Chihiro
author_sort Takahashi, Yuka
collection PubMed
description Schizophrenia is a serious psychiatric disorder that affects the social life of patients. Psychiatric disorders are caused by a complex combination of genetic (G) and environmental (E) factors. Polysialylation represents a unique posttranslational modification of a protein, and such changes in neural cell adhesion molecules (NCAMs) have been reported in postmortem brains from patients with psychiatric disorders. To understand the G × E effect on polysialylated NCAM expression, in this study, we performed precise measurements of polySia and NCAM using a disrupted-in-schizophrenia 1 (DISC1)-mutant mouse (G), a mouse model of schizophrenia, under acute stress conditions (E). This is the first study to reveal a lower number and smaller length of polySia in the suprachiasmatic nucleus of DISC1 mutants relative to those in wild-type (WT) mice. In addition, an analysis of polySia and NCAM responses to acute stress in five brain regions (olfactory bulb, prefrontal cortex, suprachiasmatic nucleus, amygdala, and hippocampus) revealed that the pattern of changes in these responses in WT mice and DISC1 mutants differed by region. These differences could indicate the vulnerability of DISC1 mutants to stress.
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spelling pubmed-91027872022-05-14 Polysialylation in a DISC1 Mutant Mouse Takahashi, Yuka Abe, Chikara Hane, Masaya Wu, Di Kitajima, Ken Sato, Chihiro Int J Mol Sci Article Schizophrenia is a serious psychiatric disorder that affects the social life of patients. Psychiatric disorders are caused by a complex combination of genetic (G) and environmental (E) factors. Polysialylation represents a unique posttranslational modification of a protein, and such changes in neural cell adhesion molecules (NCAMs) have been reported in postmortem brains from patients with psychiatric disorders. To understand the G × E effect on polysialylated NCAM expression, in this study, we performed precise measurements of polySia and NCAM using a disrupted-in-schizophrenia 1 (DISC1)-mutant mouse (G), a mouse model of schizophrenia, under acute stress conditions (E). This is the first study to reveal a lower number and smaller length of polySia in the suprachiasmatic nucleus of DISC1 mutants relative to those in wild-type (WT) mice. In addition, an analysis of polySia and NCAM responses to acute stress in five brain regions (olfactory bulb, prefrontal cortex, suprachiasmatic nucleus, amygdala, and hippocampus) revealed that the pattern of changes in these responses in WT mice and DISC1 mutants differed by region. These differences could indicate the vulnerability of DISC1 mutants to stress. MDPI 2022-05-06 /pmc/articles/PMC9102787/ /pubmed/35563598 http://dx.doi.org/10.3390/ijms23095207 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takahashi, Yuka
Abe, Chikara
Hane, Masaya
Wu, Di
Kitajima, Ken
Sato, Chihiro
Polysialylation in a DISC1 Mutant Mouse
title Polysialylation in a DISC1 Mutant Mouse
title_full Polysialylation in a DISC1 Mutant Mouse
title_fullStr Polysialylation in a DISC1 Mutant Mouse
title_full_unstemmed Polysialylation in a DISC1 Mutant Mouse
title_short Polysialylation in a DISC1 Mutant Mouse
title_sort polysialylation in a disc1 mutant mouse
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102787/
https://www.ncbi.nlm.nih.gov/pubmed/35563598
http://dx.doi.org/10.3390/ijms23095207
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