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Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells

SIMPLE SUMMARY: Temozolomide (TMZ) is the first-line drug in the treatment of glioblastoma. Due to the formation of the DNA damage O(6)-methylguanine, it is toxic to cancer cells, resulting in the induction of apoptosis. However, the damage also induces cellular senescence. Here, we show that not ap...

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Detalles Bibliográficos
Autores principales:	Beltzig, Lea, Schwarzenbach, Christian, Leukel, Petra, Frauenknecht, Katrin B. M., Sommer, Clemens, Tancredi, Alessandro, Hegi, Monika E., Christmann, Markus, Kaina, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102829/ https://www.ncbi.nlm.nih.gov/pubmed/35565362 http://dx.doi.org/10.3390/cancers14092233

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