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Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
The Golgi apparatus is at the center of protein processing and trafficking in normal cells. Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor microenvironment and the immune landscape, which enhances the invasive and metastatic potential of cancer cells. Among...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102947/ https://www.ncbi.nlm.nih.gov/pubmed/35563790 http://dx.doi.org/10.3390/cells11091484 |
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author | Bajaj, Rakhee Warner, Amanda N. Fradette, Jared F. Gibbons, Don L. |
author_facet | Bajaj, Rakhee Warner, Amanda N. Fradette, Jared F. Gibbons, Don L. |
author_sort | Bajaj, Rakhee |
collection | PubMed |
description | The Golgi apparatus is at the center of protein processing and trafficking in normal cells. Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor microenvironment and the immune landscape, which enhances the invasive and metastatic potential of cancer cells. Among these changes in the Golgi in cancer include altered Golgi orientation and morphology that contribute to atypical Golgi function in protein trafficking, post-translational modification, and exocytosis. Golgi-associated gene mutations are ubiquitous across most cancers and are responsible for modifying Golgi function to become pro-metastatic. The pharmacological targeting of the Golgi or its associated genes has been difficult in the clinic; thus, studying the Golgi and its role in cancer is critical to developing novel therapeutic agents that limit cancer progression and metastasis. In this review, we aim to discuss how disrupted Golgi function in cancer cells promotes invasion and metastasis. |
format | Online Article Text |
id | pubmed-9102947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91029472022-05-14 Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis Bajaj, Rakhee Warner, Amanda N. Fradette, Jared F. Gibbons, Don L. Cells Review The Golgi apparatus is at the center of protein processing and trafficking in normal cells. Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor microenvironment and the immune landscape, which enhances the invasive and metastatic potential of cancer cells. Among these changes in the Golgi in cancer include altered Golgi orientation and morphology that contribute to atypical Golgi function in protein trafficking, post-translational modification, and exocytosis. Golgi-associated gene mutations are ubiquitous across most cancers and are responsible for modifying Golgi function to become pro-metastatic. The pharmacological targeting of the Golgi or its associated genes has been difficult in the clinic; thus, studying the Golgi and its role in cancer is critical to developing novel therapeutic agents that limit cancer progression and metastasis. In this review, we aim to discuss how disrupted Golgi function in cancer cells promotes invasion and metastasis. MDPI 2022-04-28 /pmc/articles/PMC9102947/ /pubmed/35563790 http://dx.doi.org/10.3390/cells11091484 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bajaj, Rakhee Warner, Amanda N. Fradette, Jared F. Gibbons, Don L. Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis |
title | Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis |
title_full | Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis |
title_fullStr | Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis |
title_full_unstemmed | Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis |
title_short | Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis |
title_sort | dance of the golgi: understanding golgi dynamics in cancer metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102947/ https://www.ncbi.nlm.nih.gov/pubmed/35563790 http://dx.doi.org/10.3390/cells11091484 |
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