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Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis

The Golgi apparatus is at the center of protein processing and trafficking in normal cells. Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor microenvironment and the immune landscape, which enhances the invasive and metastatic potential of cancer cells. Among...

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Detalles Bibliográficos
Autores principales: Bajaj, Rakhee, Warner, Amanda N., Fradette, Jared F., Gibbons, Don L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102947/
https://www.ncbi.nlm.nih.gov/pubmed/35563790
http://dx.doi.org/10.3390/cells11091484
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author Bajaj, Rakhee
Warner, Amanda N.
Fradette, Jared F.
Gibbons, Don L.
author_facet Bajaj, Rakhee
Warner, Amanda N.
Fradette, Jared F.
Gibbons, Don L.
author_sort Bajaj, Rakhee
collection PubMed
description The Golgi apparatus is at the center of protein processing and trafficking in normal cells. Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor microenvironment and the immune landscape, which enhances the invasive and metastatic potential of cancer cells. Among these changes in the Golgi in cancer include altered Golgi orientation and morphology that contribute to atypical Golgi function in protein trafficking, post-translational modification, and exocytosis. Golgi-associated gene mutations are ubiquitous across most cancers and are responsible for modifying Golgi function to become pro-metastatic. The pharmacological targeting of the Golgi or its associated genes has been difficult in the clinic; thus, studying the Golgi and its role in cancer is critical to developing novel therapeutic agents that limit cancer progression and metastasis. In this review, we aim to discuss how disrupted Golgi function in cancer cells promotes invasion and metastasis.
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spelling pubmed-91029472022-05-14 Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis Bajaj, Rakhee Warner, Amanda N. Fradette, Jared F. Gibbons, Don L. Cells Review The Golgi apparatus is at the center of protein processing and trafficking in normal cells. Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor microenvironment and the immune landscape, which enhances the invasive and metastatic potential of cancer cells. Among these changes in the Golgi in cancer include altered Golgi orientation and morphology that contribute to atypical Golgi function in protein trafficking, post-translational modification, and exocytosis. Golgi-associated gene mutations are ubiquitous across most cancers and are responsible for modifying Golgi function to become pro-metastatic. The pharmacological targeting of the Golgi or its associated genes has been difficult in the clinic; thus, studying the Golgi and its role in cancer is critical to developing novel therapeutic agents that limit cancer progression and metastasis. In this review, we aim to discuss how disrupted Golgi function in cancer cells promotes invasion and metastasis. MDPI 2022-04-28 /pmc/articles/PMC9102947/ /pubmed/35563790 http://dx.doi.org/10.3390/cells11091484 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bajaj, Rakhee
Warner, Amanda N.
Fradette, Jared F.
Gibbons, Don L.
Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
title Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
title_full Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
title_fullStr Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
title_full_unstemmed Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
title_short Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
title_sort dance of the golgi: understanding golgi dynamics in cancer metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102947/
https://www.ncbi.nlm.nih.gov/pubmed/35563790
http://dx.doi.org/10.3390/cells11091484
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