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Alginate: Enhancement Strategies for Advanced Applications

Alginate is an excellent biodegradable and renewable material that is already used for a broad range of industrial applications, including advanced fields, such as biomedicine and bioengineering, due to its excellent biodegradable and biocompatible properties. This biopolymer can be produced from br...

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Detalles Bibliográficos
Autores principales: Hurtado, Alejandro, Aljabali, Alaa A. A., Mishra, Vijay, Tambuwala, Murtaza M., Serrano-Aroca, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102972/
https://www.ncbi.nlm.nih.gov/pubmed/35562876
http://dx.doi.org/10.3390/ijms23094486
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author Hurtado, Alejandro
Aljabali, Alaa A. A.
Mishra, Vijay
Tambuwala, Murtaza M.
Serrano-Aroca, Ángel
author_facet Hurtado, Alejandro
Aljabali, Alaa A. A.
Mishra, Vijay
Tambuwala, Murtaza M.
Serrano-Aroca, Ángel
author_sort Hurtado, Alejandro
collection PubMed
description Alginate is an excellent biodegradable and renewable material that is already used for a broad range of industrial applications, including advanced fields, such as biomedicine and bioengineering, due to its excellent biodegradable and biocompatible properties. This biopolymer can be produced from brown algae or a microorganism culture. This review presents the principles, chemical structures, gelation properties, chemical interactions, production, sterilization, purification, types, and alginate-based hydrogels developed so far. We present all of the advanced strategies used to remarkably enhance this biopolymer’s physicochemical and biological characteristics in various forms, such as injectable gels, fibers, films, hydrogels, and scaffolds. Thus, we present here all of the material engineering enhancement approaches achieved so far in this biopolymer in terms of mechanical reinforcement, thermal and electrical performance, wettability, water sorption and diffusion, antimicrobial activity, in vivo and in vitro biological behavior, including toxicity, cell adhesion, proliferation, and differentiation, immunological response, biodegradation, porosity, and its use as scaffolds for tissue engineering applications. These improvements to overcome the drawbacks of the alginate biopolymer could exponentially increase the significant number of alginate applications that go from the paper industry to the bioprinting of organs.
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spelling pubmed-91029722022-05-14 Alginate: Enhancement Strategies for Advanced Applications Hurtado, Alejandro Aljabali, Alaa A. A. Mishra, Vijay Tambuwala, Murtaza M. Serrano-Aroca, Ángel Int J Mol Sci Review Alginate is an excellent biodegradable and renewable material that is already used for a broad range of industrial applications, including advanced fields, such as biomedicine and bioengineering, due to its excellent biodegradable and biocompatible properties. This biopolymer can be produced from brown algae or a microorganism culture. This review presents the principles, chemical structures, gelation properties, chemical interactions, production, sterilization, purification, types, and alginate-based hydrogels developed so far. We present all of the advanced strategies used to remarkably enhance this biopolymer’s physicochemical and biological characteristics in various forms, such as injectable gels, fibers, films, hydrogels, and scaffolds. Thus, we present here all of the material engineering enhancement approaches achieved so far in this biopolymer in terms of mechanical reinforcement, thermal and electrical performance, wettability, water sorption and diffusion, antimicrobial activity, in vivo and in vitro biological behavior, including toxicity, cell adhesion, proliferation, and differentiation, immunological response, biodegradation, porosity, and its use as scaffolds for tissue engineering applications. These improvements to overcome the drawbacks of the alginate biopolymer could exponentially increase the significant number of alginate applications that go from the paper industry to the bioprinting of organs. MDPI 2022-04-19 /pmc/articles/PMC9102972/ /pubmed/35562876 http://dx.doi.org/10.3390/ijms23094486 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hurtado, Alejandro
Aljabali, Alaa A. A.
Mishra, Vijay
Tambuwala, Murtaza M.
Serrano-Aroca, Ángel
Alginate: Enhancement Strategies for Advanced Applications
title Alginate: Enhancement Strategies for Advanced Applications
title_full Alginate: Enhancement Strategies for Advanced Applications
title_fullStr Alginate: Enhancement Strategies for Advanced Applications
title_full_unstemmed Alginate: Enhancement Strategies for Advanced Applications
title_short Alginate: Enhancement Strategies for Advanced Applications
title_sort alginate: enhancement strategies for advanced applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102972/
https://www.ncbi.nlm.nih.gov/pubmed/35562876
http://dx.doi.org/10.3390/ijms23094486
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